HSPA5


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HSPA5

A gene on chromosome 9q33.3 that encodes a member of the heat shock 70 (HSP70) family which is localised in the lumen of the endoplasmic reticulum, where it is involved in protein folding and assembly. 

Molecular pathology
HSPA5 is an autoantigen implicated in the pathogenesis of rheumatoid arthritis.
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References in periodicals archive ?
These genes were divided into two networks: one network was interlocking histone genes clusters and another network consisted of 39 genes, which included several important node genes such as EGFR, FOS, HSPA5, TLR4, and MMP9 (Figure 3).
Identification of Significant Pathways Induced by PAX5 Haploinsufficiency Based on Protein-Protein Interaction Networks and Cluster Analysis in Raji Cell Line
In summary, aging and epigenetic regulation dominate bladder carcinogenesis through CALR, PDIA3, DNAJB11, HSPA5, RPN1, HSP90B1, KPNA2, ECT2, and PSMD11 and through COPS5, PSMD8, RNF126, CALR, PDIA3, HSP90B1, PSMD12, PSMD11, JUN, HN1, and ENO1, respectively.
The design of a multiple drug combination for treating stage 1 bladder cancer depends on a strategy of inhibiting the highly expressed genes ADRM1, COPS5, PSMD8, SUMO2, CALR, PDIA3, DNAJB11, HSPA5, RPN1, CUL1, HSP90B1, KPNA2, PSMD12, ECT2, TK1, TUBA1C, HN1, and ENO1; activating the suppressed genes UBC, JUN, RARRES3, and FOS; and suppressing the drug's effect on the nondifferentially expressed genes BAG6, HUWE1, PAAF1, PSMD10, FAF2, PCYT1A, and PSMD10.
The design of a multiple drug combination for treating stage 4 bladder cancer depends on a strategy of inhibiting the highly expressed genes ADRM1, COPS5, PSMD8, SUMO2, RNF126, CALR, PDIA3, DNAJB11, HSPA5, RPN1, HSP90AA1, HSPA1B, METTL23, RARRES3, KPNA2, PSMD12, ECT2, JUN, TK1, TUBA1C, HN1, and ENO1; activating the suppressed genes BCL3, FOS, UBC, and GTF2A1; and suppressing the drug's effect on the nondifferentially expressed genes, which are the same as those in stage 1 bladder cancer.
The major factors, including downregulated miR12, the aging-related proteins, HSP90B1, CALR, HSPA5, PDIA3, RPN1, and ECT2, the smoking-related proteins, HUWE1, HSPA5, and ECT2, and the epigenetic regulation of ENO1, HSP90B1, CALR, and PDIA3, lead to the progression from normal bladder cells to stage 1 bladder cancer cells through the SUP and ER signaling pathways.
Network biomarkers of bladder cancer based on a genome-wide genetic and epigenetic network derived from next-generation sequencing data
This is the first study to suggest a panel of HSPs (Dnaja 1, Dnajb4,Hsp90aa 1, Hsp90ab 1, Hspa 1 b, Hspa5, and Hspa8) as effector genes in response to [O.sub.3] -induced TLR4 signaling.
Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70
The epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), and heat shock protein A member 5 (HSPA5) were the top three hubs, indicating highest connectivity and greatest capacity to regulate the interaction network (Figures 4 and 5).
Quantitative PCR was performed to confirm expression changes of proteins with highest connectivity, including EGFR, TP53, HSPA5, excision repair cross-complementation group 1 (ERCC1), and X-ray repair cross complementing 1 (XRCC1), in several prostate cell lines.
HSPA5 is also overexpressed in some cancers, including breast, hepatocellular, and lung cancer [23-25].
Tseng et al., "De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells," Oncotarget, vol.
Potential Anticancer Mechanisms of a Novel EGFR/DNA-Targeting Combi-Molecule (JDF12) against DU145 Prostate Cancer Cells: An iTRAQ-Based Proteomic Analysis
miR-181b knockdown alleviated ischemic injury by upregulating HSPA5 and ubiquitin C-terminal hydrolase L1 (UCHL1) expression [29].
Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke
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