HSPA2

HSPA2

A gene on chromosome 14q24.1 that encodes a member of the heat shock 70 (HSP70 family), which stabilise pre-existent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol and within organelles.
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The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition.
The 15 screened genes were chosen for (a) their demonstrated role in regulating cellular adhesion and their possible role in metastasis (TIMP3, CDH1, CDH13, and APC), or (b) their putative role in carcinogenesis (PPP1R13B, HSPA2, HSD17B4, ESR1, GSTP1, CYP1B1, BRCA1, MYOD1, SOCS1, TITF1, and GSTM3).