HSPA1A


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HSPA1A

An intronless gene on chromosome 6p21.3 that encodes a member of the heat shock 70 (HSP70) family which, in conjunction with other heat shock proteins, stabilises extant proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. HSPA1A is a component of the so-called CatSper complex.
References in periodicals archive ?
Eight weeks of HIIT caused no significant changes in the expression of HSF-1, HSPA1A, and HSPB1 mRNA in response to lower and upper body exercises.
HIE causes upregulation of genes associated with the cellular stress response, and eight weeks of HIIT does not alter this response in HSF-1, HSPA1A, and HSPB1 mRNA.
Shkurnikov, "Effect of exercise on the expression of HSPBP1, PGLYRP1, and HSPA1A genes in human leukocytes," Bulletin of Experimental Biology and Medicine, vol.
Nowak-Zaleska, "Vitamin C, A and E supplementation decreases the expression of HSPA1A and HSPB1 genes in the leukocytes of young polish figure skaters during a 10-day training camp," Journal of the International Society of Sports Nutrition, vol.
Zychowska, "Effects of 6-week specific low-intensity training on selected aerobic capacity parameters and HSPA1A, HSPB1, and LDHB gene expression in high-level rowers," Genetics and Molecular Research, vol.
Significant genetic associations were found for the loci HSPA1B (+1267A/G) and HSPA1A (+190G/C).
In the HSPA1A (+190G/C) locus, the +190C allele was associated with the CMI development under the adjusted version of recessive model and in both additive models (O[R.sub.adj] = 5.58, p = 0.026, O[R.sub.adj] = 2.36, p = 0.011 and OR = 2, p = 0.019, respectively).
Haplotype analysis was also performed for 4 possible allele combinations for the loci HSPA1B (+1267A/G) and HSPA1A (+190G/C) (Table 2).
In particular, we found the O[R.sub.adj] = 5.58 (p = 0.026) for carriers of CC minor homozygote for the locus HSPA1A (+190G/C) and almost 4-fold statistically significant higher frequency of that genotype in individuals with the CMI diagnoses in combined group (groups 2 and 3) (16.2%) compared with the individuals from the group 1 without that diagnosis (4.3%).
The possibility that individuals homozygous for the rare G allele of HSPA1B (+1267A/G) may associate with increased expression HSPA1A and HSPA1B has not been excluded by others [15].
The haplotype examination confirmed the presence of synergistic effect between the loci HSPA1B (+1267A/G) and HSPA1A (+190G/C).