HSP90AA1

HSP90AA1

A gene on chromosome 14q32.33 that encodes an inducible homodimeric molecular chaperone with intrinsic ATPase activity, which aids proper folding of specific target proteins. HSP90AA1 promotes the maturation, structural maintenance and proper regulation of client proteins involved in cell cycle control and signal transduction, as well as other processes.
References in periodicals archive ?
The smoking-related protein HSP90AA1 and DNA methylation of ECT2 mediate the progression from stage 1 bladder cancer cells to metastasis in stage 4 bladder cancer.
The design of a multiple drug combination for treating stage 4 bladder cancer depends on a strategy of inhibiting the highly expressed genes ADRM1, COPS5, PSMD8, SUMO2, RNF126, CALR, PDIA3, DNAJB11, HSPA5, RPN1, HSP90AA1, HSPA1B, METTL23, RARRES3, KPNA2, PSMD12, ECT2, JUN, TK1, TUBA1C, HN1, and ENO1; activating the suppressed genes BCL3, FOS, UBC, and GTF2A1; and suppressing the drug's effect on the nondifferentially expressed genes, which are the same as those in stage 1 bladder cancer.
001 survival CASP1, CBR1, CRABP2, CSTB, EEF1A1, EIF6, ENO1, FLNA, GAPDH, HMGB2, HSP90AA1, HSP90AB1, HSPA8, HSPB1, ITGB4, KRT14, KRT6A, KRT8, LMNA, NDRG1, PDCD6IP, PRDX2, S100A8, S100A9, SFN, TF, TPM1, TRIM29, TUBB, TUBB3, TXN, VCL, YWHAZ Cancer ANXA2, ENO1, 11 < .