There was also a reduction in cellular Hsp72
expression in cells from inflammation-bearing mice that were pretreated with thymulin or the inhibitor (Figure 4).
Febbraio e colaboradores (2004), mostraram que a ingestao de glicose atenua a liberacao de IL-6 e tambem de HSP72
e HSP60 durante 2h de ciclismo a 60% do [VO.sub.2max].
As shown in Figure 4A, [E.sub.2] and TAM treatments resulted in 9-fold increases in levels of the hsp70 inducible protein hsp72
compared with control levels (p < 0.01).
In the latter species, hsp72
appears to be constitutive, with moderately increased synthesis after moderate temperature shock, and down-regulation at the highest temperature tested (35 [degrees] C).
Caillaud, "Effect of age on Hsp72
expression in leukocytes of healthy active people," Experimental Gerontology, vol.
Table 2 Effect of adaptogens, presumably adaprogens and other plants extracts on release of NPY and Hsp72
proteins from isolated human neuroglia cells.
Quercetin suppresses heat shock-induced nuclear translocation of Hsp72
. Folia Histochemi.
The 70-kDa heat shock protein Hsp72
plays a central role in the mechanism that rids the cell of stress-induced misfolding or incompletely synthesized polypeptides that otherwise would interfere with normal cellular function, thereby playing critical roles in maintaining cellular homeostasis and in protecting the cell from stressful conditions and increase cell survival in the face of otherwise lethal cellular stress.
Also, it is observed that there is an influence on the expression of hsp72
, which protects cells and tissues from the deleterious effects of free radicals.
Under the heat stress, Hsp72
functions as a molecular chaperone .
HSP expression levels seasonal variation: Semi-quantitative expression analysis of HSP was done on three isoforms, HSP73, HSP72
and HSP69, using RIU.
NSAIDs have been shown to upregulate various stress proteins in in vitro and in vivo studies including heat shock protein 72 (HSP72
), glucose-regulated protein 78 (GRP-78), and HO-1 (Heme oxygenase-1, also known as HSP-32) .