HSPB8

(redirected from HSP22)

HSPB8

A gene on chromosome 12q24.23 that encodes a member of the (small) heat shock protein 20 family that displays temperature-dependent chaperone activity.

Molecular pathology
Defects of HSPB8 cause Charcot-Marie-Tooth disease type 2L and distal hereditary motor neuronopathy type 2A.
References in periodicals archive ?
Small heat shock proteins hsp27 (hspb1), alphab-crystallin (hspb5) and hsp22 (hspb8) as regulators of cell death.
For this purpose EGR2, MPZ, PMP22, CX32, HSP22, HSP27, LITAF, LMNA, MFN2, NEFL and HSN2 were screened and we did not found any mutation.
Joosten et al., "Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis," The Journal of Immunology, vol.
In pea plants, HSP22 was induced by heat stress, observed the expression of this protein was detected within 1 h (Wood et al., 1998).
(EDN: eosinophil-derived neurotoxin; Hsp: heat shock protein; HMGB1: high-mobility group box 1 protein.) TLRs Potential endogenous ligands TLR2 HSP60, HSP70, HSP90 fragments, hyaluronic acid, versican, HMGB1, biglycan, EDN TLR3 mRNA, dsRNA TLR4 HSP22, HSP60, HSP70, HSP72, HSP90, HMGB1, oxidised phospholipids, heparin sulfate, fibronectin, tenascin-C, [beta]-defensin 2, versican, hyaluronic acid, minimally modified-low-density lipoprotein, fibrinogen, lung surfactant protein A TLR7 U1snRNP RNA, ssRNA TLR8 ssRNA TLR9 Hypomethylated CpG-DNA