HAX1

(redirected from HSP1BP-1)

HAX1

A gene on chromosome 1q21.3 that encodes a protein which promotes cell survival. HAX1 potentiates GNA13-mediated cell migration and is involved in clathrin-mediated endocytosis. It may be involved in internalising ABC transporters (e.g., ABCB11), may inhibit CASP9 and CASP3, and may regulate intracellular calcium pools.

Molecular pathology
Defects of HAX1 cause Kostmann disease (severe congenital neutropenia autosomal recessive type 3).
References in classic literature ?
NOT long ago, the writer of these lines, In the mad pride of intellectuality, Maintained "the power of words"--denied that ever A thought arose within the human brain Beyond the utterance of the human tongue: And now, as if in mockery of that boast, Two words-two foreign soft dissyllables-- Italian tones, made only to be murmured By angels dreaming in the moonlit "dew That hangs like chains of pearl on Hermon hill,"-- Have stirred from out the abysses of his heart, Unthought-like thoughts that are the souls of thought, Richer, far wider, far diviner visions Than even the seraph harper, Israfel,(Who has "the sweetest voice of all God's creatures") Could hope to utter.
How often must I urge you to seek that absolute concentration of your mental faculties which alone may permit you to bring to bear the highest powers of intellectuality upon the momentous problems which naturally fall to the lot of great minds?
As an exquisite embodiment of the poet's visions, and a realisation of human intellectuality, gilding with refulgent light our dreamy moments, and laying open a new and magic world before the mental eye, the drama is gone, perfectly gone,' said Mr Curdle.