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Joseph Kim, Inovio's President and CEO, said, "We are very excited to expand the target indication for VGX-3100 to treat rare and difficult to treat diseases like anal HSIL, which have a high recurrence rate that requires multiple, repeat surgeries.
Stier, M.D., from the Boston University School of Medicine, and colleagues used data from the multicenter AIDS Malignancy Consortium 084 study to evaluate the prevalence of and risk factors for anal HSILs among 256 WLHIV (median age, 49.4 years).
The histopathologic features of bowenoid papulosis overlap significantly with those of basaloid HSIL (Bowen disease).
It also included 4 cases of AGUS, 3 cases were of LSIL, 7 cases were of HSIL and 2 cases were of invasive squamous cell carcinoma and 1 case of adenocarcinoma cervix.
It was specimens of SCC derived from patients who had undergone total hysterectomy, and HSIL specimens were derived from patients who had undergone the loop electrosurgical excision procedure (LEEP) or cone biopsy.
There were 46.15% (6/13) of samples with ASC-US, 57.14% (4/7) with ASC-H, 70.97% (22/31) with LSIL, 80.36% (45/56) with HSIL, and 90.48% (19/21) with invasive squamous cell carcinoma (chi-square test = 10.7682, p = 0.029296, p < 0.05).
One case of HSIL was observed in Grade I and Grade II of p53 expression comprising 50.00% of cases each.
Among all 854 abnormal findings (excluding normal colposcopy), 40.3% were diagnosed as normal/benign, 29.4% were diagnosed as LSIL, 28.1% were diagnosed as HSIL, and 2.2% were diagnosed as cancerous.
None of the women with serial Pap smears progressed to HSIL. The majority of women (34,77%) with a negative or ASCUS first Pap did not progress beyond ASCUS.
In our follow-up of 54 unsatisfactory anal Pap cases with biopsy follow-up, distribution of squamous intraepithelial lesions (57.4%), HSIL (19%), and negative cases was not statistically significant when compared with that of Morency et al.
Manish Bhatia(President, BPD business, HSIL) added,"We have carefully studied the changing consumer needs over the last 56 years and basis of this, all our innovations bring out something meaningful every time.
Cell experts rated the anal cell samples according to a standard system that starts with normal cells and progresses to high-grade squamous intraepithelial neoplasia (HSIL), which can lead to anal cancer (Figure 1).
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