HSF5

HSF5

A gene on chromosome 17q22 that encodes a member of the DNA-binding heat-shock transcription factor family, which are rapidly induced by temperature and other forms of intracellular stress.
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DE genes Samples Upregulated Downregulated C versus Pcdhgb2 Ubd, Ttr, M [intersection] F Cxcl9, Serpina3n, versus Irg1, Odf1, Trpv4 M [intersection] A versus M F versus Ifit1, AABR06089930.1, M [intersection] C LOC100912860 Cd80, versus M Tfec, Il1rn A versus Alas2, Plac8, C3, M [intersection] C Angptl1, Bcl2a1, S100a4, versus M Cndp1 Il15ra, Ptprcap, Lgals3, Ccl2, LOC691141, Ptx3, Itgal, Pram1, Hk3, Pate4, A2m F versus Ada, Hsf5, Rn50_1_2682.1, M [intersection] A Slc16a12 Cd22 versus M Table 3: Common significant GO terms for DE genes.
(a) microRNA miR-516-5p miR-517 * miR-526a miR-525 miR-520a * Number of 349 179 212 340 352 predicted target genes Unique target genes Shared with miR-525 CCR2 FAS BCAP29 TOX ACVR2B CD109 IL6ST CD24 AHSA2 CD1A IL9R CD302 ATRN DNAJC25 IRAK3 CFLAR CD2 FLT1 LILRA2 DNAJC21 CD300LB IL17RE MTDH HSP90AA1 CD46 IRAK1 PAPPA IGFBP1 CD93 LILRB5 TLR2 HSF5 PDCD6IP TNFRSF19 IGF1R SOCS2 TNFSF15 IL10RA TRAF6 MMD2 PPARA TLR7 VSIG4 All the targets were predicted by a bioinformatics tool MirTarget2 using miRDB online database.
Gene Product Otoa NM_139310 Otoancorin Cabp2 NM_013878 Calcium binding protein 2 Sod3 NM_011435 Superoxide dismutase 3 Hspb8 NM_030704 Heat shock protein 8 Hsf5 NM_001045527 Heat shock transcription factor member 5 Otof NM_031875 Otoferlin Calca NM_007587 Calcitonin/calcitonin-related polypeptide alpha Pcdha4 NM_007766 Protocadherin alpha 4 Gene Symbol Fold Change p-Value Otoa +3.4 0.04 Cabp2 +1.6 0.003 Sod3 +2.0 0.03 Hspb8 +1.3 0.02 Hsf5 +1.8 0.02 Otof -1.8 0.04 Calca -1.9 0.04 Pcdha4 -1.3 0.001 Table 2.