HSF4

HSF4

A gene on chromosome 16q21 that encodes a member of the DNA-binding heat-shock transcription factor family, which are rapidly induced by temperature and other forms of intracellular stress. HSF4 is thought to downregulate DNA-binding activity.
References in periodicals archive ?
Forty-five genes implicated in the CC, including 29 nonsyndromic cataract genes ( AGK , BEST1 , BFSP1 , BFSP2 , CHMP4B , CRYAA , CRYAB , CRYBA1 , CRYBA4 , CRYBB1 , CRYBB2 , CRYBB3 , CRYGC , CRYGD , CRYGS , EPHA2 , FYCO1 , GJA3 , GJA8 , HSF4 , P3H2 , LIM2 , MAF , MIP , NHS , PITX3 , SLC16A12 , TDRD7 , and VIM ) and 16 syndromic cataract genes ( ABHD12 , CNBP , CTDP1 , EYA1 , FTL , GALK1 , GCNT2 , GFER , GJA1 , JAM3 , OPA3 , PAX6 , RAB3GAP2 , SIL1 , SIX6 , and SLC33A1 ), were collected from careful literature and database search.
(63) Saydamligi ve dolayisiyla islevi hucrelerinin hidrasyonu ve hacmiyle dogrudan ilgili olan lenste nutrisyon, hidrasyon ve atik urunlerin uzaklastirilmasi gibi gorevleri olan major intrinsik protein, konneksinler ve lens intrinsik membran protein 2'yi kodlayan genletdeki (MIP, GJA3, GJA8, LIM2) mutasyonlar da bu islevleri bozarak kataraktogenezde rol alirlar (63) Lensin embriyolojik gelisiminde gorev yapan bircok ttansktipsiyon faktorunu kodlayan genlerdeki (PITX3, PAX6, FOXE3, EYA1, MAF, HSF4) mutasyonlar da katataktla iliskilendirilmistir.