HSF1

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HSF1

A gene on chromosome 8q24.3 that encodes a member of the DNA-binding heat-shock transcription factor family, which are rapidly induced by temperature and other forms of intracellular stress. HSF1 is repressed by Hsp90 and/or multi-chaperone complexes.

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HSF2

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Heat stress (H + W) induced a slight increase in the expression level of both HSF3 and HSF1. This effect was significantly increased when blue light was applied during heat stress (H + B).

Modulatory Effect of Monochromatic Blue Light on Heat Stress Response in Commercial Broilers

HSP90 is one of the heat shock proteins reported to function as multichaperone complexes by combining with different cochaperones (Cdc37, p23, Hop, pP5, SGT1, Aha 1, etc.) affecting binding ability of HSP90 to client proteins (AKT, KIT, ErbB2, CDK 4, HSF1, Apaf-1, MMp2, etc.) [43].

In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity.

Composition and expression of heat shock proteins in an invasive pest, the rice water weevil (Coleoptera: Curculionidae)

The HSF1 "plays a crucial role in the response of brain cells to prenatal environmental insults," the researchers reported.

Life stressors in expectant mothers could trigger neurological disorders in babies

Both Hsps regulate the activation of the HSF1 transcription factor, which is linked to the transcriptional stress response [33, 34].

Essential role of thioredoxin 2 in mitigating oxidative stress in retinal epithelial cells

Induction of heat shock proteins by hyperthermia and noise overstimulation in hsf1 -/- mice.

Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures

The member of the Hsf family, Hsf1 is involved in the Hsps induction owed to heat shock and other kinds of stress (8-10).

Respuesta celular de linea de hepatoma humano (HepG2) al estres hipotermico con recuperacion. Induccion de la expresion de Hsp60, Hsp70, y Hsf1

The gene, called heat-shock factor 1 (Hsf1), doesn't itself trigger cancer.

Aiding and abetting: a longevity gene also promotes cancer

In addition, decreases in ATP levels have been previously found to elicit the induction of HSPs by DNA binding and activation of the transcriptional factor HSF1 (39).

Cardiac protein expression patterns are associated with distinct inborn exercise capacity in non-selectively bred rats

In NAFLD&NASH, we observed that oxidative stress could activate epidermal growth factor receptor (EGFR) to facilitate (i) UBC to repress HSF1 in the WNT and MAPK signaling pathways; (ii) APP to activate ETS1 in the MAPK signaling pathway to induce DNA repair function through the mediation of RFC5, to activate metabolism through the mediation of TRMT1, and to inhibit apoptosis through the mediation of ZNF480; and (iii) SHC1 to repress STAT5A in the MAPK signaling pathway.

Investigating Pathogenic and Hepatocarcinogenic Mechanisms from Normal Liver to HCC by Constructing Genetic and Epigenetic Networks via Big Genetic and Epigenetic Data Mining and Genome-Wide NGS Data Identification