HSF1


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HSF1

A gene on chromosome 8q24.3 that encodes a member of the DNA-binding heat-shock transcription factor family, which are rapidly induced by temperature and other forms of intracellular stress. HSF1 is repressed by Hsp90 and/or multi-chaperone complexes.
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Even in mice where the HSF1 gene was properly activated to combat environmental insults, the molecular mechanism alone may permanently change how brain cells respond, and may be a reason why someone may be more susceptible to neuropsychiatric disorders later in life.
For the heat shock response, ultrasensitive motifs increasing loop amplification include homotrimerization of transcription factor HSF1 (heat shock factor protein 1) and cooperative binding of the HSF1 trimer to the promoters of heat shock genes (Liu and Thiele 1999; Xiao et al.
Interestingly, heat shock rapidly induces CG synthesis followed by HSF1 activation and HSP70 induction in human fibroblasts.
Recently it was observed that dynamic changes in the cholesterol-rich domain structure induced by heat stress or benzyl alcohol (membrane fluidizer) treatment is responsible for the activation of HSF1 and HSP70.
HSF1 and its target genes are important to metabolism regulation.
GHSU scientists accomplished this by removing HSF1 from the mice; HSF1 inhibitors are under development because of their potential for treating a variety of other cancers such as breast, prostate and kidney cancers.
The damage to early-state rat neurons was much lower in cells pre-treated with the HSF1 activator, and damage to the neurons of fruit flies that had a Huntington's-like disorder was also greatly reduced.
1995) revealed that the levels of the two isoform of HSF1 mRNA were regulated in a tissue-dependent manner in mice.
The heat-sock transcription factor HSF1 is rapidly activated by either hyper- or hypo-osmotic stress in mammalian cells.