EDNRB

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EDNRB

A gene on chromosome 13q22 that encodes endothelin-B receptor, a member of the endothelin receptor group of G-protein-coupled
receptors, located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation.

Molecular pathology
EDNRB mutations cause Hirschsprung disease type 2.
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Knowledge about which Veterans are at high risk of screening positive for housing instability could inform refinements to the implementation of the HSCR, ensuring that it is administered in a way that efficiently uses clinician and system resources.
We identified the study sample using data collected from Veteran respondents to the HSCR. The two questions that comprise the HSCR are:
Intestinal neuronal dysplasia type B was first described as a finding in rectal biopsies from patients who underwent biopsy to exclude HSCR. These patients were typically younger than 1 year and had clinical features suggestive of HSCR (eg, constipation, abdominal distension, bilious emesis).
Many challenges need to be overcome before applying hESC/hiPSC-derived-NCSCs into HSCR clinical trials; nonetheless, cell-based and drug-based therapies for HSCR by using hESC/hiPSC-derived-NCSCs remain a promising prospect.
This could be verified by neurexin and neuroligin expressing in postsynapse and presynapse of ENS, respectively, and their functions in the pathogenesis of HSCR, as reported in our previous study [12].
Moreover, the total colonic type has a morbidity up to 55.4%.[sup][13] Down syndrome (DS) is the most frequent congenital disease that accompanies HSCR. HAEC presents a higher rate with the coexistence of HSCR and DS.[sup][14] Patients who have underwent multistage surgery and laparotomy demonstrated a higher morbidity.[sup][9],[15]
A further cysteine radical mutation at the 620 position was related to MEN2 in 3 families, plus 1 other unique family referred from elsewhere, in which MEN and HSCR co-existed.
The standard approach for diagnosing HSCR is the rectal suction biopsy.
We analyzed germline mutations in genes encoding protein members of the RET and EDNRB signaling pathways to investigate how mutations in those genes correlate with the manifestation of the disease in Chinese HSCR patients.
If it were necessary to scan all exons for mutations (as is the case in HSCR), this would be too daunting, even for a small number of patients.
Suryadev Alloys And Power (P) Ltd produces both billets and reinforcement steel rebars from 8 mm to 40 mm both ordinary and HSCRS with Thermex (German) technology.