spherocytosis, hereditary, type 4

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spherocytosis, hereditary, type 4

An autosomal haematologic disorder (OMIM:612653) characterised by numerous abnormally shaped, generally spheroid erythrocytes accompanied by chronic haemolytic anaemia.

Molecular pathology
Caused by defects of SLC4A1, which encodes a protein with an N-terminal 40kDa domain that is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin.
References in periodicals archive ?
MacLeod, Greenvale, Isle of Scalpay, HS4 3YA, tel 01859- 540268.
The Hydrosnubber HS4 and HS4W, for Branson IW Series welders ($625 and $675 respectively), control the contact rate during welding without restricting down speed, thus preventing cracked parts and incompletely staked heads.
The contract is to provide funding in the form of a lease to finance the 6 pieces weighing systems and RFID systems as retrofitting IVECO65C14G running hook HS4.
A request for proposal (RFP) has been issued by Arabsat for the procurement of four new satellites: the HS3, HS4, ARB6E and ARB6A, set to launch in 2016 and 2017.
Hellas-Sat s current HS2 would probably be substituted by the HS3 and HS4 satellites at 39 degrees east with additional capacities in Ku- and Ka-band.
The new satellites are HS3, HS4, AR6E and AR6A, which will be positioned at 3 different orbital locations with a coverage over Middle Eastern, African, Asian and European markets with high power DTH payload in Ku bands and Ka spot beams capacities.