spherocytosis, hereditary, type 3

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spherocytosis, hereditary, type 3

An autosomal recessive haematologic disorder (OMIM:270970) characterised by numerous abnormally shaped, generally spheroid erythrocytes accompanied by severe haemolytic anaemia.

Molecular pathology
Caused by defects of SPTA1, which encodes an alpha erythrocyte spectrin and major scaffold protein linking the plasma membrane to the actin cytoskeleton.
References in periodicals archive ?
Although HS3 is a separate decision for the Government, there needs to be better links from the North East to the North West, with Luke saying: "Investment in the North needs to be prioritised.
Using data from two Global Hawk (GH) UASs, the HS3 goal was to better understand the physical processes that control intensity change, specifically the relative roles of environmental and inner-core processes.
But the announcement of HS3 is a long way shy of any solid commitment to speed up trains across the north of England.
The government work with Transport for the North to produce a comprehensive transport strategy for the region, which will include options, costs and a delivery timetable for a HS3 east west rail connection.
The two new HS3 and HS4 satellites will be favourable to the replacement of Hellas-Sat's current HS2 at 39A East orbital slot with additional capacities in Ku and Ka bands payload brought to customers with great flexibilities.
The HS3 and HS4 satellites will replace Hellas-Sat's current HS2 at the 39 degrees East orbital slot and HS4 will, additionally, provide Arabsat with prime Ku-band capacity over Europe and the Mediterranean, which will complement the existing in-orbit capacity .
NASA will fly two Global Hawks from Wallops during the HS3 mission.
HS3 seeks to improve our understanding of these processes by taking advantage of the surveillance capabilities of the Global Hawk along with measurements from a suite of advanced instruments," (http://www.
The Dresser Wayne Vista HS3 dispensers deliver up to 80 GPM flow rate through the master and satellite hoses.
Secondly, we need to push forward with plans to develop HS3 to connect east and west.
Now a senior Kirklees councillor has claimed moves to spend PS9bn on a 30-minute rail route between Leeds and Manchester - the socalled HS3 scheme - could scupper the plan.