spherocytosis, hereditary, type 3

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spherocytosis, hereditary, type 3

An autosomal recessive haematologic disorder (OMIM:270970) characterised by numerous abnormally shaped, generally spheroid erythrocytes accompanied by severe haemolytic anaemia.

Molecular pathology
Caused by defects of SPTA1, which encodes an alpha erythrocyte spectrin and major scaffold protein linking the plasma membrane to the actin cytoskeleton.
References in periodicals archive ?
The Hurricane and Severe Storm Sentinel (HS3) mission, funded under NASA's Earth Venture program, comprised a set of aircraft and payloads well suited for the study of hurricanes and other severe weather systems.
The Government has already committed [pounds sterling]60m to preparatory work on the HS3 line between Manchester and Leeds and options are already being considered for a trans-Pennine tunnel between Manchester and Sheffield as well as improvements to the A66, A69 and the north-west quadrant of the M60, he said.
As part of the government's radical proposals to improve transport in the north, HS3 is expected to significantly reduce journey times across the region and is anticipated to be a crucial element in creating a northern powerhouse which will transform the economy in the region, according to a report published by the chairman of HS2, Sir David Higgins.
He wants an HS3 rail link for the north of England.
Arabsat has announced the release of a request for proposal (RFP) for the procurement of four new satellites to be designated HS3, HS4, AR6E and AR6A.
Arab Satellite Communication Organisation (Arabsat) today announced the release of a request for proposal for the procurement of four satellites to be designated HS3, HS4, AR6E and AR6A.
The topology is based on a 1200-V IGBT4 HS3 (high speed) in the half-bridge and 600-V IGBT3 with low saturation voltage in the commutating path.
HS2 SEs grew normally and consistently with 2-week subculture intervals, but with a 3-week interval, the HS3 SEs grew slowly and then stopped until the medium was changed again.
Amhuinnsuidhe Castle Estate Isle of Harris Outer Hebrides HS3 3AS Tel: +44 (0)1859 560200 Fax: +44 (0)1859 560263 BESPOKE HAMPERS PERSONALISED ORDERS CORPORATE DISCOUNTS
With the Hurricane and Severe Storm Sentinel (HS3) mission, NASA for the first time will be flying Global Hawks from the U.S.
HS3 seeks to improve our understanding of these processes by taking advantage of the surveillance capabilities of the Global Hawk along with measurements from a suite of advanced instruments," (http://www.nasa.gov/mission_pages/hurricanes/missions/hs3/news/hs3.html) stated Scott Braun, HS3 mission principal investigator and research meteorologist at Nasa's Goddard Space Flight Center in Greenbelt, Maryland.