To investigate the ability of Heidelberg Retina Tomograph (HRT3) Topographic Change Analysis (TCA) map to predict the subsequent development of clinical change, in patients with glaucoma.
In the currently available software (HRT3), progression is defined as a cluster of 20 or more significantly depressed superpixels [9, 10].
At enrollment in the prospective study, 27/61 clinically stable eyes were classified as TCA-stable and 34/61 clinically stable eyes were classified as TCA-progressed according to HRT3 progression criteria.
While HRTII software was used for image acquisition in the preenrollment period, HRT3 was used for image acquisition in the prospective period.
Nevertheless, the commercially available HRT3 software, we used in the current study, does not have the ability to delineate a significant cluster of superpixels within the ONH margin if it belongs to a larger cluster that is extended partially outside the optic disc as well.