HEYL

(redirected from HRT3)

HEYL

A gene on chromosome 1p34.3 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEYL is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It interacts with ARNT, GATA4, GATA6, HES1, HEY1, HEY2, HDAC1, NCOR1 and SIN3A
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In vivo confocal microscopy (HRT3; Heidelberg Engineering, Dossenheim, Germany) was used to observe epithelial and stromal inflammatory changes of the corneal graft and the distribution of dendritic cells.
previously reported that optic disc size had a significant effect on the HRT3 classification, with an estimated 21% increase in the odds of a positive glaucoma probability score (GPS) classification and a 15% positive Moorfields regression analysis (MRA) classification for each 0.1 [mm.sup.2] increase in disc size [17].
To investigate the ability of Heidelberg Retina Tomograph (HRT3) Topographic Change Analysis (TCA) map to predict the subsequent development of clinical change, in patients with glaucoma.
In the currently available software (HRT3), progression is defined as a cluster of 20 or more significantly depressed superpixels [9, 10].
At enrollment in the prospective study, 27/61 clinically stable eyes were classified as TCA-stable and 34/61 clinically stable eyes were classified as TCA-progressed according to HRT3 progression criteria.
While HRTII software was used for image acquisition in the preenrollment period, HRT3 was used for image acquisition in the prospective period.
Nevertheless, the commercially available HRT3 software, we used in the current study, does not have the ability to delineate a significant cluster of superpixels within the ONH margin if it belongs to a larger cluster that is extended partially outside the optic disc as well.