Hirschsprung disease

(redirected from HRSD)
Also found in: Acronyms.

con·gen·i·tal meg·a·co·lon

, megacolon congenitum
congenital dilation and hypertrophy of the colon due to absence (aganglionosis) or marked reduction (hypoganglionosis) in the number of ganglion cells of the myenteric plexus of the rectum and a varying but continuous length of gut above the rectum; seen in humans and dogs.

Hirschsprung disease

A condition of infant onset characterised by the absence of myenteric nerves in the distal colon, extending proximally from the anus for a variable distance. It affects an estimated 1:5000 live births, and is more common in males (male:female ratio, 4:1); up to 10% have Down syndrome. 

Clinical findings
Failure to pass meconium or stool in first 24 hours post-partum; abdominal distention; vomiting; constipation at birth. Peristalsis is absent in aganglionic segment, causing proximal pseudo-obstruction and gross dilatation, enterocolitis and perforation. In older children, Hirschsprung disease is characterised by chronic constipation, abdominal distention and stunted growth.

Diagnosis
By rectal suction biopsy; must include submucosa, taken at least 2 cm above pectinate line.

Management
Resection of aganglionic segment, guided by intraoperative frozen sections from myenteric plexus.

con·gen·i·tal meg·a·co·lon

, megacolon congenitum (kŏn-jen'i-tăl meg'ă-kō-lŏn, kon-jen'i-tŭm)
Congenital dilation and hypertrophy of the colon due to absence (aganglionosis) or marked reduction (hypoganglionosis) in the number of ganglion cells of the myenteric plexus of the rectum and a varying but continuous length of colon above the rectum.
Synonym(s): Hirschsprung disease.

Hirschsprung disease

Hirschsprung disease is a congenital abnormality (birth defect) of the bowel in which there is absence of the ganglia (nerves) in the wall of the bowel. Nerves are missing starting at the anus and extending a variable distance up the bowel. This results in megacolon (massive enlargement of the bowel) above the point where the nerves are missing. (The nerves are needed to assist in the natural movement of the muscles in the lining of the bowels that move bowel contents through.)
Mentioned in: Ostomy

Hirschsprung,

Harald, Danish physician, 1830-1916.
Hirschsprung disease - congenital dilation and hypertrophy of the colon. Synonym(s): congenital megacolon
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HRSD also anticipates rate increases of 9% per year over that same period (2018 through 2022).
A study of levetiracetam, 1500 mg/d, showed no significant change in HRSD, YMRS, or ACT scores from baseline to end point for either levetiracetam or placebo.
De 41 pacientes controlados, 17 (41,5%) estaban deprimidos segun el BDI y la HRSD; de 59 pacientes no controlados, 42 (71,1%) segun el BDI y 41 (69,5%) segun la HRSD estaban deprimidos (p < 0,003 y p < 0,005, respectivamente).
The mean HRSD change scores at these time points were 10 and 9.6 for the standard group and 11.3 and 11.1 for the software group.
Depression was deemed likely in the four subjects not assessed by a psychiatrist on grounds of high readings on both HRSD and MADRS assessments (greater than 16 and 19, respectively).
No significant differences were determined between these groups in terms of HRSD scores and disease duration.
Response was defined as a 50% reduction in Hamilton Rating Scale for Depression (HRSD).
Although this rate was based on individual physician assessment and retrospective review of patient medical records, it corresponds well with studies using the Hamilton Rating Scale for Depression (HRSD) as a measure of clinical improvement.
The Hampton Roads Sanitation District (HRSD) is the regional authority for wastewater treatment and disposal.
Securities and Exchange Commission, assigned ratings to Hampton Roads Sanitation District, VA (HRSD, or the district) revenue bonds.
The 17-item Hamilton Rating Scale for Depression (HRSD) was the primary outcome measure.
Response was reported as the relative risk of response (RR) and was defined as a greater than 50% decrease in the Hamilton Rating Scale for Depression (HRSD) and Montgomery-Asberg Depression Rating Scale (MADRS).