EDAR

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EDAR

A gene on chromosome 2q13 that encodes ectodysplasin A receptor, a member of the tumour necrosis factor receptor family, which is a receptor for the soluble ligand ectodysplasin A. Once bound, EDAR activates the nuclear factor-kappaB, JNK and caspase-independent cell death pathways. EDAR is required for the development of hair, teeth and other ectodermally derived tissues.

Molecular pathology
EDAR mutations result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
References in periodicals archive ?
Figure 1 shows PCR products of 16SrRNA gene of HRM1 or HS1 isolates and the standard P.
HRM1 colony was highly bioluminescent and gave dark yellow color on LB media, whereas, HS1 colony was less bioluminescent and gave light yellow color on LB media.
Inhibition zones were measured (mm) for the primary form of HRM1 and HS1 against a panel of pathogenic microorganisms, including Staphylococcus sp.
Also, no significant variations between antibiotic activity of HRM1 and HS1 with all pathogenic bacteria were obtained.
akhurstii type strains HRM1 and HS1 against variable bacterial pathogens.
Phenotypic characteristics of the studied bacterial strains HRM1 and HS1 have also been confirmed by studies of Fischer-Le Saux et al.