n the Phase 1 trial run at the KEM hospital, 74 healthy volunteers were randomized into several groups that either received escalating doses of RAB-1 or of HRIG combined with vaccine.
150 mg/kg had levels of rabies antibodies equal to or higher than the levels from those volunteers who had received the standard does of HRIG and vaccine.
2-Kokarca, rakun, yarasa, tilki ve diger et oburlar ile dag sicanlari ile temas varsa: Cografi bolgede kuduz olmadigi bilinmedikce veya laboratuvar testleriyle hayvanin kuduz olmadigi gosterilmedikce hayvan kuduz kabul edilerek acilen asilama ile birlikte HRIG veya ERIG uygulanir.
HRIG 20 IU/kg veya ERIG 40 IU/kg yara yeri cevresine uygulanir.
should not be administered in the same syringe as vaccine.
Rabies vaccine 19 $ 189 ($ 80-$ 594) HRIG 2 mL 17 $ 136 ($ 67-$ 400) 10 mL 17 $ 504 ($268-$1577) PEP For persons weighing 33 lbs(2) 14 $1127 ($481-$3371) For persons weighing 132 lbs(3) 16 $1430 ($709-$4233) For persons weighing 165 lbs(4) 16 $1498 ($787-$4548)
1) PEP consists of doses of rabies vaccine and HRIG based on the patient's weight.
Because vaccine and HRIG
administered after onset of disease is of no known benefit, postexposure treatment for patients after onset of clinical rabies is not recommended.
The essential components of rabies postexposure prophylaxis are local wound treatment and the administration, in most instances, of both HRIG and vaccine (Table 2).
Studies conducted in the United States by CDC have shown that a regimen of one dose of HRIG and five doses of HDCV over a 28-day period was safe and induced an excellent antibody response in all recipients (15).
Suppression has been observed with the 2-1-1 IM schedule when PVRV or other TC-derived vaccines, including Purified Chick Embryo Cell and Purified Duck Embryo Cell, were administered with 20 IU/kg of HRIG