At the high end, several targets had more than a hundred candidate reference chemicals (AR, ESR1, HRH1
, DRD2, OPRM1, HRH2), while at the low end, 5 targets had no reports in any of the sources (DIO, DIO3, NR2A2, SLC16A2, SRD5A3).
Cornejo-Garcia et al., "Variability in histamine receptor genes HRH1
, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs," Pharmacogenomics, vol.
We compared our dataset with a curated list of a total 601 genes and molecules implicated in psychological depression (IPA) and found 13 genes common showing significant differential methylation (Figure 2, Supplement 4), including BTG2, FABP6, GRIN1, HRH1
, HSD17B1, MDFI, OXT, and TSPO.
HTR2C, CHRM2, ADRA2B, HTR6, HTR5A, ADRA2C, HTR7, DRD2, and DRD4; SLC6A4, ADRA1A, HTR1A, ADRA1B, HTR2A, and DRD1; OPRL1, CHRM5, CHRM1, ADRB1, ADRA2A, and HRH1
; and CHRM4, CHRM3, KCNH2, SLC6A4, CYP2D6, SCN1A: four clusters of neuronal GPCRs (G-proteincoupled receptors: adrenergic, cholinergic, histamine, and serotonin receptors).
The inventors have filed another patent for the use of medicament containing interfering RNA that targets histamine receptor H1 (HRH1