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At the high end, several targets had more than a hundred candidate reference chemicals (AR, ESR1, HRH1, DRD2, OPRM1, HRH2), while at the low end, 5 targets had no reports in any of the sources (DIO, DIO3, NR2A2, SLC16A2, SRD5A3).
Cornejo-Garcia et al., "Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs," Pharmacogenomics, vol.
We compared our dataset with a curated list of a total 601 genes and molecules implicated in psychological depression (IPA) and found 13 genes common showing significant differential methylation (Figure 2, Supplement 4), including BTG2, FABP6, GRIN1, HRH1, HSD17B1, MDFI, OXT, and TSPO.
HTR2C, CHRM2, ADRA2B, HTR6, HTR5A, ADRA2C, HTR7, DRD2, and DRD4; SLC6A4, ADRA1A, HTR1A, ADRA1B, HTR2A, and DRD1; OPRL1, CHRM5, CHRM1, ADRB1, ADRA2A, and HRH1; and CHRM4, CHRM3, KCNH2, SLC6A4, CYP2D6, SCN1A: four clusters of neuronal GPCRs (G-proteincoupled receptors: adrenergic, cholinergic, histamine, and serotonin receptors).
The inventors have filed another patent for the use of medicament containing interfering RNA that targets histamine receptor H1 (HRH1) mRNA.
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- HRH The Princess of Wales