HRAS

(redirected from HRAS1)

HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.
References in periodicals archive ?
Overexpression of hepatocyte growth factor or Hras1 causes an increase in dermal melanocytes in transgenic mice.
Hypomethylation of the promoter region of oncogenic Hras1 and an elevated Hras1 mRNA level was demonstrated in mice treated with sodium arsenite (Okoji et al.
Pierce LM, Sivaraman L, Chang W, Lum A, Donlon T, Seifried A, Wilkens LR, Lau AF, Marchand LL (2000) Relationships of TP53 codon 72 and HRAS1 polymorphisms with lung cancer risk in an ethnically diverse population.
De esta manera se han encontrado amplificaciones en algunos de esos genes y se ha observado hasta el momento que su presencia en ciertas poblaciones podria estar contribuyendo a aumentar el riesgo a padecer: enfermedad bipolar cuando hay amplificacion en el gen SEF2-1B, OMIM 602272; autismo cuando estan en el gen RELN, OMIM 600514; sindrome de Jacobsen en el gen CBL2, OMIM 147791; cancer de ovarios en el gen hRAS1, OMIM 190020 y cancer de prostata en el gen NCOA3, OMIM 601937 (Anonimo 2004).
The HRAS1 variable number of tandem repeats and risk of breast cancer.
The HRAS1 minisatellite locus and risk of ovarian cancer.
HRAS1 codes for a protein that helps control the timing of cell division and differentiation.
N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.
DNA samples were isolated from bloodsamples and the investigators located areas at the tip of chromosome 11 containing one gene responsible for the production of insulin and another, called Ha-ras-1 (HRAS1), that produces a protein believed to be involved in benign forms of cancer.
In the two oldest Amish generationsunder study, specific forms of insulin and HRAS1 appeared in combination only among those with a mood disorder.