HRAS

(redirected from HRAS1)

HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.
References in periodicals archive ?
Pierce LM, Sivaraman L, Chang W, Lum A, Donlon T, Seifried A, Wilkens LR, Lau AF, Marchand LL (2000) Relationships of TP53 codon 72 and HRAS1 polymorphisms with lung cancer risk in an ethnically diverse population.
The HRAS1 variable number of tandem repeats and risk of breast cancer.
The HRAS1 minisatellite locus and risk of ovarian cancer.
HRAS1 codes for a protein that helps control the timing of cell division and differentiation.
In the two oldest Amish generationsunder study, specific forms of insulin and HRAS1 appeared in combination only among those with a mood disorder.