HRAS


Also found in: Dictionary, Thesaurus, Financial, Acronyms, Encyclopedia, Wikipedia.

HRAS

A gene on chromosome 11p15.5 belonging to the Ras oncogene family, the protein products of which bind GTP and GDP, have intrinsic GTPase activity, and play key roles in signal transduction. HRAS cycles between de- and re-palmitoylation, a reaction that regulates its rapid exchange between the plasma membrane and the Golgi apparatus.

Molecular pathology
Defects in HRAS are associated with an increased risk of bladder cancer, Hürthle cell carcinoma of thyroid, and oral squamous cell carcinoma. HRAS mutations cause faciocutaneoskeletal syndrome and congenital myopathy with excess of muscle spindles—a variant of Costello syndrome.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
All reported the key to getting members to complete an HRA is finding the right incentives and that the HRA is only the beginning of a broader member conversation.
The process of implementing online HRAs requires that employers provide electronic eligibility files to the HRA administrators.
Other provisions of the new FSA and HRA rollover guidance note that:
Employers that offer regular workplace coverage can also set up another type of HRA account -- limited to $1,800 a year -- that will allow workers to get additional benefits such as dental and vision care.
To be eligible to provide a qualified small employer HRA, an employer must not be an "applicable large employer" (ALE), defined by Sec.
The guidance further addresses the timing, format, and contents of a required written notification of the HRA to employees, how employees may prove they have minimum essential coverage (with a model attestation document as an appendix), and substantiation requirements for reimbursed medical expenses.
In addition, Pearson's correlation coefficients analysis was used for the correlation of LCK and HRAS, RAS isoforms, and BRAF at transcriptional level, respectively.
Further, the employee must be given the opportunity to opt out of the HRA coverage.
HRA supporters say the Obama administration applied the PPACA rules to HRAs and other cash-for-coverage arrangements in that way because the administration was afraid small employers would push employees into the PPACA public exchange system.
Due to the positive federal income tax and payroll tax treatment of employer contributions to retirees' HRAs, as described in PLR 201528004, these arrangements can be a valuable benefit.
52% said that consumers don't grasp the long-term benefits of HSAs and HRAs.
Kura Oncology, a United States-based biopharmaceutical company, has commenced dosing in the Phase II clinical trial of tipifarnib in patients with locally advanced tumours that carry HRAS mutations, it was reported on Tuesday.