human papillomavirus

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any member of a genus of viruses that cause papillomas in humans and various other animals.
human papillomavirus any of numerous species that cause warts, particularly plantar and venereal warts, on the skin and mucous membranes in humans, transmitted by either direct or indirect contact. They have also been associated with cervical cancer.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hu·man pap·il·lo·ma·vi·rus (HPV),

an icosahedral DNA virus, 55 nm in diameter, of the genus Papillomavirus, family Papovaviridae; certain types cause cutaneous and genital warts; other types are associated with severe cervical intraepithelial neoplasia and anogenital and laryngeal carcinomas. Over 70 types have been characterized on the basis of DNA relatedness.

HPV infection is the most common viral sexually transmitted disease. A single unprotected contact with an infected person carries a 60% risk of infection. The interval between exposure and clinical evidence of disease ranges from 3 weeks to 8 months. The annual incidence of genital HPV infection in the U.S. is estimated to be 3.5 million cases, with a prevalence of current infection of 20 million. More than one half of all sexually active women have been infected with one or more genital HPV types. About 15% have DNA evidence of current infection and 1% have genital warts. Most HPV infections are subclinical and transitory, the median duration of infection being about 8 months, with persistence rates of 30% at 1 year and 9% at 2 years. However, some types of HPV can induce genetic mutations in cervical epithelium that can culminate, after a latent period of 10-20 years, in the development of cancer. Carcinoma of the cervix is the most common malignancy in women under age 50. In the U.S., the incidence of cervical cancer is 8.3/100,000, with approximately 14,000 cases and 1,000 deaths annually. As many as 98% of all cancers of the cervix (most of which are squamous cell carcinomas) are believed to be induced by infection with HPV types 16, 18, 31, 33, and a few others. HPV typing in women with atypical squamous cells of undertermined significance (ASC-US) on cervical Papanicolaou smear helps to identify those in whom more intensive surveillance for premalignant change is warranted. Women with external genital warts (condylomata acuminata, which are usually due to HPV type 6 or 11) are not at increased risk of cervical cancer and do not need special surveillance if routine Papanicolaou smears are negative. Some 40% of HIV-positive women develop severe cervical dysplasia caused by HPV, which in many cases proceeds to fatal cancer with an aggressiveness not commonly seen among non-HIV-positive women. Diagnosis of HPV infection is based on visual inspection (including colposcopy with application of acetic acid to the cervix), Papanicolaou smear, and biopsy, with detection of viral DNA in tissue. Treatment options depend on the site and extent of involvement and include surgical excision, cryotherapy with liquid nitrogen, topical application of bichloracetic acid or trichloracetic acid, laser ablation, loop electrosurgical excision, and intralesional injection of interferon. External genital warts usually respond to topical treatment with podofilox gel or imiquimod (a cytokine-inducing agent that can be applied by the patient). Subclinical HPV infection, detectable only by Papanicolaou smear or other laboratory methods, may prove impossible to eradicate. The virus cannot be cultured, and there is no test to confirm cure. In limited trials, a vaccine has demonstrated efficacy in preventing both HPV-16 infection and HPV-related cervical intraepithelial neoplasia in women not previously exposed to the virus.

Farlex Partner Medical Dictionary © Farlex 2012

human papillomavirus

n. Abbr. HPV
Any of various genera of papillomaviruses that cause cutaneous and genital warts in humans, with some strains associated with cervical, anogenital, or laryngeal carcinomas.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A DNA virus that causes warts on acral parts which, in those with multiple sexual partners, may be premalignant, especially in those infected with types 16, 18, 31, 33 or 65 genotypes of HPV  have been described. A genotype is distinct if it has < 50% DNA sequence similarity or “homology” with its closest relative. HPV has been identified by in situ hybridisation in epithelial proliferations that are benign (e.g., condyloma acuminatum), or malignant (e.g., squamous cell carcinoma of the penis, anus, and uterine cervix) or of uncertain clinical behaviour (e.g., inverted papillomas of the nasopharynx).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

human papillomavirus

See HPV.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

hu·man pa·pil·lo·ma·vi·rus

(HPV) (hyū'măn pap'i-lō'mă-vī'rŭs)
DNA virus of the genus Papillomavirus; certain types cause cutaneous and genital warts in humans, including verruca vulgaris and condyloma acuminatum; other types are associated with severe cervical intraepithelial neoplasia and anogenital and laryngeal carcinomas. Over 70 types have been characterized on the basis of DNA relatedness.
Synonym(s): infectious papillomavirus.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

human papillomavirus (HPV)

A member of the Papoviridae family that replicate in the nucleus of the host cell. HPV is the cause of common warts (HPV types 2, 4), flat warts (10), genital warts (6, 11), cervical intraepithelial neoplasia (6, 11, 16, 18, 31, 40, 42, 44), cervical cancer (mainly 16, 18), penile cancer and laryngeal cancer (mainly 16). The highest-risk HPV types are believed to be 16, 58, 31, 18, 56, 35, 33, 45, 52,39, 51 and 59.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Human papillomavirus (HPV)

A large family of viruses, some of which cause genital warts; HPV can be transmitted to a fetus during birth.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about human papillomavirus

Q. hpv Can i get pregnant

A. You can get pregnant you just need to tell your doctor whats going on so he can keep an eye on the issue.

Q. Should I Vaccinate My Daughter Against HPV? I have a 12 year old daughter. Her School wants all the girls aged 12 and up to be vaccinated against HPV. A lot of Parents are against this vaccine. I want to know more about this vaccine and if I should vaccinate my daughter.

A. before you would like to go on with any vaccination, you should check out this very long list of links:

at the bottom you will also find links in english. vaccinations in general are very disputable/dubious and it is probably time that we learn about it.

Q. Is there a natural cure for hpv?

More discussions about human papillomavirus
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References in periodicals archive ?
The rapid HPV test that will be provided at an affordable price to developing countries holds tremendous promise.
18 New England Journal of Medicine, researchers report that HPV tests caught many more cases of cervical cancer than Pap smears did.
However, in women over 30, where the presence of high risk HPV types often indicates that the infection has not been resolved, it is recommended to use both the HPV test and the Pap test."
It must be taken into account that a negative HPV test result without cytology can result in a false sense of security, while an unsatisfactory Pap test would trigger a follow-up repeat, or, in a symptomatic patient, a concurrent or follow-up biopsy.
The FDA recommended that women who test positive for HPV 16 or HPV 18 using the cobas HPV test have a colposcopy.
HPV Test: In this test, smears taken from the cervix are checked for the presence of HPV and its types:
They defined high-risk HPV persistence as a positive high-risk HPV test followed by at least two consecutive tests that were not both negative.
The Abbott RealTime High Risk HPV test is a real-time PCR-based assay for concurrent detection and individual genotyping of HPV-16 and HPV-18 and pooled detection of 12 other hrHPV genotypes: HPV-31, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-56, HPV-58, HPV-59, HPV-66, and HPV-68.
As a result, a positive HPV test result had a lower positive predictive value than did a positive Pap smear: Only 12% of women with positive HPV tests had CIN 2 or worse lesions, compared with 91% of those with positive Pap smears.
In this letter I report a preliminary study in which the HPV test was evaluated against histology in all cases.
Researchers, who were led in the ( study by Mona Saraiya of the Centers for Disease Control in Atlanta, say HPV is common in women in their 20s and most often doesn't lead to cancer after 25 percent of doctors gave female patients the wrong type of HPV test, and nearly two-thirds gave the test to the wrong patients, in addition to testing their patients too often, according to the study.
* Age 30 and older: Ask for an HPV test together with your Pap test.