CDH17

(redirected from HPT1)

CDH17

A gene on chromosome 8q22.1 that encodes cadherin 17, which is a component of the GI tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of medically important peptide-based drugs. Cadherin 17 may also play a role in the morphological organisation of the liver and intestine.
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One explanation may be the gain or over-expression of genes such as FAK, FGFR1, EXT1, ASAP1, ADAM9, HPT1, RHOBTB2, and SYCL associated with cell adhesion, cell-cell contacts, migration and extracellular matrix interactions.
TABLE 1 Rank Order With Sums for 25 Graphics (n = 9) Graphic Sum Mean Rank Order PerformanceImprovementModels13 -20 -2.00 1 PerformanceImprovementModels12 -6 -.60 2 ProblemStatement24 -4 -.40 3 PerformanceProblem15 0 .00 4 Intervention6 2 .20 5 Performanceanalysis8 2 .20 6 HPT3 4 .40 7 PerformanceProblem16 4 .40 8 ProblemStatement2 5 8 .80 9 CauseAnalysis17 10 1.00 10 Intervention5 12 1.20 11 Performanceanalysis10 12 1.20 12 Intervention4 14 1.40 13 Performanceanalysis9 14 1.40 14 PerformanceProblem14 16 1.60 15 ProblemStatement23 16 1.60 16 CauseAnalysis19 18 1.80 17 PerformanceGap22 18 1.80 18 PerformanceImprovementModels11 20 2.00 19 PerformanceGap20 20 2.00 20 CauseAnalysis18 22 2.20 21 HPT2 24 2.40 22 Intervention7 24 2.40 23 HPT1 24 2.67 24 PerformanceGap21 28 2.80 25