CDH17

(redirected from HPT-1)

CDH17

A gene on chromosome 8q22.1 that encodes cadherin 17, which is a component of the GI tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of medically important peptide-based drugs. Cadherin 17 may also play a role in the morphological organisation of the liver and intestine.
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The loss rates after challenging bake cycles have shown the superior performance of HPT-1, HPT-2 and HPT-3, compared with standard BTZ, BP, and Ox absorbers.
HPT-1 and HPT-2 show almost similar absorption spectra due to only a small difference in [R.
This new product form is denoted as, for example, HPT-1 DW, whereas DW stands for dispersible in water.
Figure 5 shows the visual appearance of the exposed panels stabilized with BTZ-1, HPT-1 and HPT-3 at 20 and 40 [micro]m dry film thickness (DFT).
It is quite obvious that BTZ-1 is almost entirely gone after 54 months of exposure, whereas HPT-1 and HPT-3 are still present in the coating.