Correlation of HOXB9, HOXB13, and HOXD13 Expressions with Clinicopathological Features of LSCC Patients.
Relationship between HOXB9, HOXB13, and HOXD13 Expressions and Survival of LSCC Patients.
Among them, HOXB9, HOXB13, and HOXD13 had the highest expression levels and were further investigated using a prognostic tissue microarray (TMA).
Of the upregulated genes (15 of the 39 members), HOXB9, HOXB13, and HOXD13 were identified as the top 3 overexpressed HOX genes (fold change > 14).
Our finding showed that the top 3 genes (HOXB9, HOXB13, and HOXD13) were all overexpressed and that high HOXB9 expression was significantly associated with a high histological grade and poor prognosis of patients with LSCC.
A similar expression pattern was observed regarding HOXD13. As another important member of the 13 paralogous HOX genes, the aberrant expression of HOXD13 has been reported in different tumor types [35-37].
In conclusion, our study demonstrated the presence of three marked upregulated HOX genes (HOXB9, HOXB13, and HOXD13) in LSCC.
Wang et al., "HOXD13 methylation status is a prognostic indicator in breast cancer," International Journal of Clinical & Experimental Pathology, vol.
Among the 15 HOX genes, HOXB9, HOXB13, and HOXD13 show the most significant increase in expression in LSCC compared to noncancerous tissues.
Caption: Figure 3: Immunohistochemical analysis of HOXB9, HOXB13, and HOXD13 expressions.
Caption: Figure 4: Survival analysis of the correlation of high/low (a) HOXB9, (b) HOXB13, and (c) HOXD13 expressions with overall survival in the patients with LSCC.