Regulation of the Hoxa4 and Hoxa5
genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning.
undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.
overexpression in bone marrow CD34+ SCs and cord blood CD34+ CD38- cells resulted in a significant shift in myeloid differentiation .
Starting with 26 transcription factors identified as likely candidates, they eventually came down to just five (RUNX1, ERG, LCOR, HOXA5
and HOXA9) that were both necessary and sufficient for creating blood stem cells.
Gorski, "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5
," Blood, vol.
MiR-130a contributes to angiogenesis by suppressing antiangiogenic homeobox gene GAX and HOXA5
in endothelial cells.
miR-130a stimulates angiogenesis by inhibiting GAX and HOXA5
, while, miR-296 acts through the inhibition of hepatocyte growth factor-(HGF-) regulated tyrosine kinase .
Regulation of angiogenesis through a microRNA (miR-130a) that downregulates antiangiogenic homeobox genes GAX and HOXA5
. Blood 2008;111(3):1217-1226.
function can limit p53 expression in human breast tumours.
Of tumor samples taken from 30 women with breast cancer, 20 were devoid of the protein, called HOXA5
, says study coauthor Saraswati Sukumar, a molecular biologist at the Johns Hopkins Medical Institutions in Baltimore.
was selected because of multiple DMRs extending through the HOXA gene cluster.
Using the dCas9-SunTag-DNMT3A complex, researchers methylated a region of 4.5 kb residing the Hoxa5
gene with fairly low off-target to on-target ratio .