HOXA5

HOXA5

A gene on chromosome 7p15.2 that encodes a DNA-binding transcription factor, which provides cells with specific positional identities along the anterior-posterior axis during embryonic development and is involved in gene expression, morphogenesis and differentiation.

Molecular pathology
HOX5A methylation may result in a loss of expression of the protein product—which normally upregulates p53, the tumour suppressor—thus indirectly playing a role in cancer development.
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References in periodicals archive ?
Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning.
Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.
HOXA5. HOXA5 overexpression in bone marrow CD34+ SCs and cord blood CD34+ CD38- cells resulted in a significant shift in myeloid differentiation [25].
Starting with 26 transcription factors identified as likely candidates, they eventually came down to just five (RUNX1, ERG, LCOR, HOXA5 and HOXA9) that were both necessary and sufficient for creating blood stem cells.
Gorski, "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5," Blood, vol.
MiR-130a contributes to angiogenesis by suppressing antiangiogenic homeobox gene GAX and HOXA5 in endothelial cells.
miR-130a stimulates angiogenesis by inhibiting GAX and HOXA5, while, miR-296 acts through the inhibition of hepatocyte growth factor-(HGF-) regulated tyrosine kinase [36].
Regulation of angiogenesis through a microRNA (miR-130a) that downregulates antiangiogenic homeobox genes GAX and HOXA5. Blood 2008;111(3):1217-1226.
Of tumor samples taken from 30 women with breast cancer, 20 were devoid of the protein, called HOXA5, says study coauthor Saraswati Sukumar, a molecular biologist at the Johns Hopkins Medical Institutions in Baltimore.
Using the dCas9-SunTag-DNMT3A complex, researchers methylated a region of 4.5 kb residing the Hoxa5 gene with fairly low off-target to on-target ratio [34].