HOXA5

A gene on chromosome 7p15.2 that encodes a DNA-binding transcription factor, which provides cells with specific positional identities along the anterior-posterior axis during embryonic development and is involved in gene expression, morphogenesis and differentiation.

Molecular pathology
HOX5A methylation may result in a loss of expression of the protein product—which normally upregulates p53, the tumour suppressor—thus indirectly playing a role in cancer development.

Mentioned in ?

KDM5B

References in periodicals archive ?

Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning.

Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.

Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations in the Metabolic Syndrome

HOXA5. HOXA5 overexpression in bone marrow CD34+ SCs and cord blood CD34+ CD38- cells resulted in a significant shift in myeloid differentiation [25].

Role of HOX Genes in Stem Cell Differentiation and Cancer

Starting with 26 transcription factors identified as likely candidates, they eventually came down to just five (RUNX1, ERG, LCOR, HOXA5 and HOXA9) that were both necessary and sufficient for creating blood stem cells.

New technique raises possibility of making all types of blood cells

Gorski, "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5," Blood, vol.

From Inflammation to Current and Alternative Therapies Involved in Wound Healing

MiR-130a contributes to angiogenesis by suppressing antiangiogenic homeobox gene GAX and HOXA5 in endothelial cells.

MicroRNA as a Therapeutic Target in Cardiac Remodeling

miR-130a stimulates angiogenesis by inhibiting GAX and HOXA5, while, miR-296 acts through the inhibition of hepatocyte growth factor-(HGF-) regulated tyrosine kinase [36].

MicroRNAs in cerebral ischemia

Regulation of angiogenesis through a microRNA (miR-130a) that downregulates antiangiogenic homeobox genes GAX and HOXA5. Blood 2008;111(3):1217-1226.

The role of MicroRNAs in human diseases

Compromised HOXA5 function can limit p53 expression in human breast tumours.

Characterization and role of p53 family members in the symbiont-induced morphogenesis of the Euprymna scolopes light organ

Of tumor samples taken from 30 women with breast cancer, 20 were devoid of the protein, called HOXA5, says study coauthor Saraswati Sukumar, a molecular biologist at the Johns Hopkins Medical Institutions in Baltimore.

Silencing a gene slows breast-tumor fighter

HOXA5 was selected because of multiple DMRs extending through the HOXA gene cluster.

Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression

Using the dCas9-SunTag-DNMT3A complex, researchers methylated a region of 4.5 kb residing the Hoxa5 gene with fairly low off-target to on-target ratio [34].