HOXA2

HOXA2

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor for a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOXA2 protein may be involved in correctly positioning the hindbrain segments along the anterior-posterior axis during embryonic development.
References in periodicals archive ?
Of the 39 HOX genes, mutations in 10 HOX genes (HOXA1, HOXA2, HOXA11, HOXA13, HOXB1, HOXB13, HOXC13, HOXD4, HOXD10, and HOXD13) have been found to cause human disorders with variations in their inheritance patterns, penetrance, expressivity, and mechanisms of pathogenesis [1].
fishes contain two Hoxa2 genes, hoxa2a and hoxa2b, due to a whole genome
They said that their study enabled them to discover how expression of the key regulatory protein, encoded by the Hoxa2 gene, is controlled.
(3,4) In 1997, Vieille-Grosjean et al showed for the first time that at 4 weeks of development, human branchial arches express the paralogous groups using the mouse homologues of HOXB1, HOXA2, HOXB2, HOXA3, HOXB3, HOXD3, HOXB4, and HOXC4 as probes for in situ hybridization.
HOTAIRM1 was discovered as a myeloid-specific intergenic lncRNA of human HOXA1 and HOXA2 [61].
9:45 EVOLUTIONARY DIVERGENCE OF HOXA2 GENE EXPRESSION WITHIN THE DEVELOPING HINDBRAIN OF VERTEBRATE EMBRYOS, Adam Davis and E.
Previous studies have shown that while hoxa2a of the Japanese medaka (Oryzias latipes) shows a conserved expression pattern in the hindbrain and PAs to other osteichthyan Hoxa2 genes, medaka hoxa2b was shown to be a pseudogene, [psi]hoxa2b, which is expressed in non-canonical Hox PG2 domains, including the embryonic trunk and the pectoral fin buds.