HOXA2

HOXA2

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor for a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOXA2 protein may be involved in correctly positioning the hindbrain segments along the anterior-posterior axis during embryonic development.
References in periodicals archive ?
3,4) In 1997, Vieille-Grosjean et al showed for the first time that at 4 weeks of development, human branchial arches express the paralogous groups using the mouse homologues of HOXB1, HOXA2, HOXB2, HOXA3, HOXB3, HOXD3, HOXB4, and HOXC4 as probes for in situ hybridization.
9:45 EVOLUTIONARY DIVERGENCE OF HOXA2 GENE EXPRESSION WITHIN THE DEVELOPING HINDBRAIN OF VERTEBRATE EMBRYOS, Adam Davis and E.
Algunos genes involucrados en la morfogenesis craneofacial son: senales polarizantes (SHH,BP2,BMP4,BMP7; Smad 2-4), factores de crecimiento receptores (EGF,EGFR,TGF- alfa, TGFbeta 1-3,FGF1, FGF2, FGF8), factores de transcripcion (AP2-alfa, DLX 1-6, Gli 2 -3, PITX1, PITX2, PRX1, HOXA2, LRF6, LHX8,PAX9,MSX1,TBX1,TBX22), moleculas de adhesion celular (PBRL1, Conexin 43, E-Cadherina), matriz extracelular (COL2A1, COL11A1, COL11A2, MMP2, MMP3, MMP9, MMP13, MP1-3, fibronectina).