HOXA11

HOXA11

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOX11 is involved in regulating uterine development and is required for female fertility.

Molecular pathology
HOXA11 mutations cause radio-ulnar synostosis
with amegakaryocytic thrombocytopenia.
Mentioned in ?
References in periodicals archive ?
MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse.
Sex steroids mediate HOXA11 expression in the human periimplantation endometrium.
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.