HOXA10


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Related to HOXA10: homeo box A2

HOXA10

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. The HOXA10 protein product may play a role in fertility, embryo viability and in regulating the commitment of hematopoietic cell lineage.
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In the mice, the HOXA10 gene lost a methyl group (a carbon bound to three hydrogen atoms), permanently altering its activity and rendering uterine tissue hypersensitive to the effects of estrogen.
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.
There was significantly less HOXA10 expression in endometrial stromal cells in the antagonist compared to agonist group and natural cycles.