If the results seen in the rats hold true for humans, elevated methylation of HoxA10
may increase baby's risk of developing bone disease, such as osteoporosis, later in life, Chen says.
Dey, "Hoxa10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse," Molecular Endocrinology, vol.
Zondervan, "Coding regions of INHBA, SFRP4 and HOXA10 are not implicated in familial endometriosis linked to chromosome 7p13-15," Molecular Human Reproduction, vol.
HOXA10. HOXA10 overexpression in human cord blood and fetal liver CD34+ cells resulted in a significant production of blast cells (undifferentiated blood cells, commonly seen in acute leukemia) and myelopoiesis concomitant with a complete block of erythroid differentiation and a severe reduction in B cell development .
Taken together, these findings indicate that distinct expression patterns of HOXA5, HOXA10, HOXB6, HOXB7, HOXC4, HOXC6, HOXC8, HOXC9, HOXC10, HOXD3, and HOXD8 exist in MSCs derived from different human sources .
In the HOXA family, HOXA9 and HOXA10 showed higher expression than the remaining HOXA family genes (Figure 6(b)).
On the day of birth (PNDl), we found that Hoxa10 Hoxa11, and Hoxal3 had an expression pattern similar to that on El9, whereas Hoxa9 was more highly expressed in the oviduct compared with the uterus and cervix/ vagina.
Neonatal Gen exposure alters Hoxa gene expression in the oviduct, with Hoxa9, Hoxa10, and Hoxall expression significantly reduced compared with controls and Hoxttl3 increased.
Runx2 activity is also positively regulated by transcription factors such as TAZ, Hoxa10
, or BAPX-1 [13,14].
The researchers initially focused on DES effects and discovered that the compound alters expression of the Hoxa10
gene in mice, affecting the tissue type that grows in the uterus, cervix, and vagina.
Taylor, "HOXA10 expression is decreased in endometrium of women with adenomyosis," Fertility and Sterility, vol.
Igarashi, "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium," Journal of Clinical Investigation, vol.