HOX10 | definition of HOX10 by Medical dictionary
VSX2 (redirected from HOX10)
VSX2 A gene on chromosome 14q24.3 that encodes a homeobox protein which plays a key role in the specification and morphogenesis of the sensory retina. It may participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.
VSX2 mutations are associated with microphthalmia, cataracts and iris abnormalities.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
and Hox11 genes are required to globally pattern the mammalian skeleton.
In addition, they showed that in the absence of Hox10
function, no lumbar vertebrae are formed.
Experiments designed to elucidate a possible relationship revealed that DES acting through the estrogen receptor is inhibiting Wnt7a and that this in turn results in a failure to maintain Wnt5a (another member of the Wnt gene family) and Hox10
and Hox11 (genes for transcription factors critical in early development).