HOXA1

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HOXA1

A gene on chromosome 7p15.3 that encodes a sequence-specific transcription factor for a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOXA1 protein may be involved in correctly positioning the hindbrain segments along the anterior-posterior axis during embryonic development.
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Al and A2), bivalves possess orthologues to two anterior genes (Hox1 and Hox2), a PG-3 gene, six central class genes (PG-4, PG-5, Lox5, Hox7, Lox4, and Lox2), and two posterior class genes (Fig.
(2013) also identified 10 genes in the oyster Pinctada fucata (Hox1, Hox2, Hox3, Hox4, Hox5, Lox5, Lox4, Lox3, Post1, and Post2); however, they were not able to clearly assign another fragment (LoxZ) as ortholog of Antp/Hox7.
Numerous genes have been implicated for the pathogenesis and prognosis for T-ALL, including NOTCH1, TAL1, and HOX1 [5, 14].