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Some well-studied lncRNAs, including H19, NBR2, ARF, HOTAIR (HOX transcript antisense RNA), and NEAT1, have been shown to act as oncogenes or tumor suppressor genes, which are also correlated with drug resistance (12-16).
Hox transcript antisense RNA ( HOTAIR ), a long intervening ncRNA (lincRNA) transcribed from HOXC, is involved in epigenetic regulation, cooperative with polycomb repressive complex 2 and required for histone H3 lysine-27 trimethylation of the HOXD.
HOTAIR (HOX transcript antisense RNA), which is 2.2 kb in length and is located on 12q13.13, is a long noncoding RNA formed by HOXC gene transcription.