HOTAIR

HOTAIR

HOX transcript antisense RNA (non-protein coding). A gene on chromosome 12q13.13 that encodes long noncoding RNAs (ncRNAs), which have roles in gene regulation, especially in epigenetic control of chromatin.
References in periodicals archive ?
The specific HOTAIR primers were: forward, 5'-CAGTGGGGAACTCT GACTCG-3'; reverse, 5'-GTGCCTGGTGCTCTCTTACC-3'.
[39] identified six LncRNAs MALAT1, HOTAIR, lincRNA-p21, GAS5, TUG1, and CCND1-ncRNA in HeLa and MCF-7 cells and their secreted exosomes.
Recent reports had showed that many of the lncRNAs, including H19, HOTAIR, MALAT1, ANRIL, GAS5, and GAS5-AS1, were tumor-associated, especially in lung cancers [13-17].
Some lncRNAs (e.g., HOTAIR) are associated with chromatin-modifying complexes (e.g., polycomb repressive complex 2) to regulate epigenetic silencing of target genes [34].
These lncRNAs can act as promoters of HCC (e.g., the HOX Transcript Antisense Intergenic RNA HOTAIR, MALAT1, and HULC) [49-51] as well as tumor suppressors (e.g., p53 regulation-associated lncRNA PRAL and CPS1-IT1) [52, 53] and several of them are involved in epigenetic mechanisms of gene expression regulation [54].
But the Lib Dems have described the challenge as nothing but "hotair" as due to the electoral system it would be impossible to turn over all Lib Dem seats to Labour until 2018 at the earliest.
The Wild at Heart star (above) journeys across Africa in a hotair balloon, observing wildlife and meeting people who work to preserve animal habitats.
A BRITISH pilot and an event official suffered minor burns when a hotair balloon burst into flames and crashed in a rice paddy on the final day of the Saga International Balloon Fiesta, Asia's largest balloon festival in Japan.
A cow that gets hooked up on a hotair balloon, a hilarious throwaway gag with maids hanging on curtains and, tasteless but hysterical, Jon Lovitz and his family discovering that not all Barbie museums are to do with blonde dolls.
The denser PET is then conveyed through two dryers, first an off-the-shelf spin dryer and then a custom-built, hotair hopper dryer.
As for IncRNAs, the HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging MiR-331-3p (12), HMlincRNA717 may play crucial roles during cancer occurrence and progression (8), and ATB plays an important role in epithelial-mesenchymal transition to promote invasion and metastasis through the TGF[beta]/miR-200s/ZEB axis, resulting in a poor prognosis in GC (10).