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Abbreviation for high osmolar contrast medium.
Synonym(s): HOCA


hypertrophic obstructive cardiomyopathy.

hypertrophic cardiomyopathy

A common (1:500) condition which causes a range of mild to severe clinical and pathologic changes, which are either symmetrical (concentric) or asymmetrical (eccentric hypertrophy), with disproportionate thickening beneath the mitral valve, seen without other cardiac disease. Half are congenital with autosomal dominant patterns of inheritance—e.g., MIM 192600, MIM 160760. Obstruction is associated with reduced venous return.

Clinical findings, young patients
Range from asymptomatic to diastolic dysfunction, dyspnea, fatigue, anginal pain, syncope, an increased risk of severe obstruction, congestive heart failure, sudden death simulating acute myocardial infarction.

Clinical findings, older patients
Shortness of breath, anginal pain, syncope.

EKG Increased
QRS complexes, T-wave inversion, Q waves in inferior and left-precordial leads—which translate into asymmetric hypertrophy of the septum (usually of left side), systolic anterior movement of mitral valve, and midsystolic closure of aortic valve.

Adverse associations
Ethanol in patients with HC increases systolic blood pressure, and the pressure gradient across left ventricular outflow tract.

• Symptomatic—i.e., relief of dyspnoea or chest pain.
• Drugs—beta-adrenergics are effective short-term, calcium channel blockers (which increase diastolic ventricular filling) may be effective long-term.
• Surgery—recalcitrant cases may need a transaortic ventricular septal myotomy-myectomy.

Patient discussion about HOCM

Q. I have hypertrophic cardiomyopathy and an ICD. Is it possible to get breast implants with an ICD? I have no further symptoms: I workout and run 6 days a week, in good shape and only 27 years old.

A. Some medical equipment can damage your ICD If you are visiting your doctor , tell him or her that you have an ICD BEFORE they do any testing or treatment.i'm pretty sure they'll find a creative way to do the implant.any way- before doing any procedure- ask the cardiologist that handles you about it.

More discussions about HOCM
References in periodicals archive ?
When high CM osmolality indeed conveys beneficial effects, why pioneer HOCM (osmolalities ~1000-2500 mosmol/kg [H.
A number of additional explanations have been forwarded for the higher CIAKI incidence of HOCM versus LOCM.
Micropuncture studies in rats found that the IOCM, iotrolan, increased tubular pressure and decreased single nephron GFR much more than HOCM and LOCM did [97, 103].
139] treated human embryonic kidney cells with three different contrast media: ionic HOCM ioxitalamate, nonionic LOCM iopromide, and IOCM iodixanol.
Type Ionicity Generic name Iodine content (mg/mL) HOCM Ionic monomer Diatrizoate 300-370 HOCM Ionic monomer Metrizoate 280-370 HOCM Ionic monomer Iothalamate 141-480 LOCM Ionic dimer Ioxaglate 280-320 LOCM Nonionic monomer Iohexol 140-350 LOCM Nonionic monomer Iopamidol 150-370 LOCM Nonionic monomer Iopromide 150-400 LOCM Nonionic monomer Iopentol 150-350 LOCM Nonionic monomer Iomeprol 150-400 IOCM Nonionic dimer Iodixanol 270-320 IOCM Nonionic dimer Iotrolan 240-300 Type Osmolality Viscosity at Viscosity at 20-25[degrees] 37[degrees]C C (mPa x S) (mPa x S) HOCM 1500-2000 3.
HOCM have been compared to LOCM and lOcM have been compared against IOCM (iodixanol) for both intravenous and intra-arterial administration.
Many randomized controlled trials were performed to evaluate whether LOCM reduced the incidence of nephrotoxicity compared to HOCM.
2) Formerly used HOCMs have significantly higher incidence of adverse reactions compared to modern LOCMs.