CD57

(redirected from HNK-1)

CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.
Farlex Partner Medical Dictionary © Farlex 2012

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
PN-1007 mimics the natural HNK-1 carbohydrate epitope and binds to the circulating disease-causing antibodies.
Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1. Dev Biol.
Perturbation of cranial neural crest migration by the HNK-1 antibody.
The topics include sophisticated modes of sugar recognition by intracellular lectins involved in controlling the quality of glycoproteins, the structure and activities of natural complex polysaccharides, click chemistry in carbohydrate-based drug development, and the functional enzyme complex involved in HNK-1 carbohydrate biosynthesis.
Through biochemical and immunological techniques, the antigen in the optic tectum was tentatively identified as the human natural killer cell antigen-1 (HNK-1) carbohydrate epitope of neural cell adhesion molecule (NCAM).
To test the antigen recognized by MAB 1H12 for cross-reactivity with antibodies specific for neural cell adhesion molecule (NCAM) and the carbohydrate epitope HNK-1, immunoprecipitated antigen was electrophoresed and transferred to nitrocellulose as described above.
In contrast, immunoblot analysis with MAB VC1.1 showed that the HNK-1 carbohydrate was present on the antigen immunoprecipitated with MAB 1H12 (Fig.
In the present study, HNK-1 antibody is used to visualize the sequence of ciliary development in Capitella sp.
There is no evidence of HNK-1 reactivity during cleavage or gastrulation.
Performing immunohistochemistry labeling for Hnk-1 has allowed us to examine the patterns of crest migration.
Some neuronal components of the pharyngeal pads were visualized using indirect immunofluorescence techniques, with the HNK-1 monoclonal antibody (from the American Type Culture Collection) serving as the probe.
The HNK-1 antibody recognizes a specific carbohydrate moiety frequently found on membrane glycoproteins of neural cells (Linser, 1991; Bakker et al., 1997).