CD57

(redirected from HNK-1)

CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
References in periodicals archive ?
Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1.
Perturbation of cranial neural crest migration by the HNK-1 antibody.
The topics include sophisticated modes of sugar recognition by intracellular lectins involved in controlling the quality of glycoproteins, the structure and activities of natural complex polysaccharides, click chemistry in carbohydrate-based drug development, and the functional enzyme complex involved in HNK-1 carbohydrate biosynthesis.
Monocular enucleation of tadpoles resulted in visibly diminished HNK-1 staining of the stratum opticum in the denervated optic tectum contralateral to the enucleation.
1 showed that the HNK-1 carbohydrate was present on the antigen immunoprecipitated with MAB 1H12 (Fig.
To analyze more closely whether MAB 1H12 is specific for the HNK-1 epitope, a competitive ELISA was performed to measure what effect pre-incubation of frog brain antigen with various reagents had on subsequent recognition by 1H12-HRP conjugate (Table 1).
In the present study, HNK-1 antibody is used to visualize the sequence of ciliary development in Capitella sp.
There is no evidence of HNK-1 reactivity during cleavage or gastrulation.
Some neuronal components of the pharyngeal pads were visualized using indirect immunofluorescence techniques, with the HNK-1 monoclonal antibody (from the American Type Culture Collection) serving as the probe.
The HNK-1 antibody recognizes a specific carbohydrate moiety frequently found on membrane glycoproteins of neural cells (Linser, 1991; Bakker et al.
Sections of a pharyngeal pad immunostained with the HNK-1 antibody are shown in Figure 4D-F.