HNF1B

HNF1B

A gene on 17q12 that encodes a transcription factor that binds an inverted palindromic sequence of DNA.

Molecular pathology
Defects in HNF1B are a cause of maturity-onset diabetes of the young type 5 (MODY5, or renal cysts and diabetes syndrome) and contribute to the development of type-2 diabetes and prostate cancer hereditary type 11.
References in classic literature ?
Everybody looked at everybody else, and nobody moved; then there came a voice out of a far corner saying informally, "Rebecca, why don't you?
The case was allowed to die a natural death, and was informally dropped in 1896.
I shall leave you to judge, gentlemen, from the testimony, how far the witness in this prosecution can be so considered, feeling less reluctance to submit the case thus informally to your decision, because there is yet another indictment to be tried, which involves heavier charges against the unfortunate prisoner.
We are at home on Thursdays- today is Thursday, so please come and see us quite informally," said the governor, taking leave of him.
The Aged Man was about to speak further, but the meeting informally adjourned in order to sweep the floor of the temple - for the men of Gakwak are the tidiest housewives in all that province.
I know the Duchess very well indeed - well enough to take you to call quite informally if you please.
HNF1B, Hepatocyte nuclear factor- Transcription factor involved in 1[beta] (17) pancreatic development.
Other SNPs that reached genome-wide significance were rs401681 and rs2736098 near the TERT (telomerase reverse transcriptase) gene on chromosome 5, rs10788160 near the FGFR2 (fibroblast growth factor receptor 2) gene, rs10993994 near the MSMB (microseminoprotein, beta-) gene (as in prior studies) on chromosome 10, rs11067228 near the TBX3 (T-box 3) gene on chromosome 12, and rs4430796 at the HNF1B (HNF1 homeobox B) gene on chromosome 17.
1 HNF1B 17q12 NeuroD1 2q32 Neonatal diabetes KCNJ11 11p15.
Mutations in the HNF1B gene cause MODY5, which in affected individuals is associated with early-onset diabetes and also urogenital and renal pathology.