MMP8

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MMP8

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 8, which degrades fibrillar type I, II and III collagens. It is involved in breaking down extracellular the matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members in that it is stored in secondary granules within neutrophils and activated by autolytic cleavage.

Molecular pathology
Defects in MMP8 have been linked to arthritis and metastasis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The median age of the patients was 59 (range 17-71) years in patients with HNC. There were 9 (41%) patients with larynx, 8 (36%) nasopharynx, and 5 (23%) oral cavity/ oropharynx cancer.
Since 2015, HNC Living has awarded nearly $1 million in grants that have aided more than 1,250 head and neck cancer patients.
De Mistura on March 18 conceded he was "still detecting large distances" between the regime and the HNC. But the HNC was sanguine in its assessment, while criticising the Assad-ordered "manoeuvres".
Patients with HNC have various challenging symptoms due to their disease and treatment side effects which vary from xerostomia, taste disturbances, dietary restrictions, dysphagia and pain, fatigue, distortion of physical appearance, and permanent disfigurement to infirmity which can impact directly on the patient's QOL.
In Pakistan, HNC constitutes 21% of the cancers in men and 11% in women (Joshi et al., 2014).
In this study we aimed to develop an automatic segmentation method for HNC based on DCE-MRI by using SVM.
The Syrian government does not recognize the right of the HNC to speak on behalf of the opposition and insists they were tools of foreign powers seeking to topple the government and brand Alloush himself as a "terrorist".
The HNC suspended its involvement in the UN-brokered "proximity" negotiations with a Syrian government delegation in Geneva in April.
Muslat said the HNC would complain to the United Nations and countries backing the peace process about alleged Russian air strikes around the city of Aleppo, in an area with no fighters from the Islamic State or Nusra Front groups, excluded from the truce.
The HNC, which has convened in Riyadh to decide whether to go to Geneva, is seeking clarification from de Mistura.
* explore the potential interaction effect between the intakes of vitamin E and other selected factors--putatively associated with HNC and to our main exposure (other selected nutrients, total fruit and vegetables, supplemental use of vitamin E)--on the two HNC outcomes of interest.
Garry Bishop, senior lecturer and course leader HNC civil engineering at Teesside University, said: "I am delighted that Charlotte and Lacey have been awarded an ICE scholarship.