HMWK


Also found in: Acronyms.

HMWK

Abbreviation for high molecular weight kininogen (Fletcher factor).
Farlex Partner Medical Dictionary © Farlex 2012

HMWK

Abbreviation for high molecular weight kininogen.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Original Diagnosis Consult Type Diagnosis Cervical biopsy 3 SIL Benign Prostate biopsy 4 Carcinoma Benign Breast biopsy 3 Invasive carcinoma DCIS arising in DCIS Pleural fluid 1 Adenocarcinoma Benign Stomach biopsy 1 Adenocarcinoma Benign granulation tissue Biopsy Site/ Comment Method to Potentially Prevent Error Type Cervical biopsy No IHC done p16, MIB-1 in selected cases Prostate biopsy No IHC done p63, HMWK, AMACR in selected cases Breast biopsy No IHC done p63 in selected cases Pleural fluid No IHC done BER-EP4, MOC31 in selected cases Stomach biopsy No IHC done Keratin, CD68 in selected cases Abbreviations: DCIS, ductal carcinoma in situ; HMWK; high-molecular-weight keratin; IHC, immunohistochemistry; SIL, squamous intraepithelial lesion.
The use of IHC for high-molecular-weight keratin (HMWK) and [alpha]-methylacyl coenzyme A racemase (AMACR), either individually or in combination, has been studied extensively in prostate pathology practice, primarily as a tool in confirming and establishing cancer diagnosis on prostate needle biopsy and for evaluating challenging and questionable foci in prostate specimens, particularly on needle biopsy.
Therefore, in this study we sought to describe in detail the use of IHC in routine evaluation of prostate needle biopsy practice in a tertiary academic institution and to examine the quality assurance implications of the use of IHC for HMWK and AMACR, such as the biopsy turnaround times when IHC was used, the final diagnosis rendered on specific cores, and the intradepartmental consultation performed in this setting, as well as the cost analysis of IHC for routine evaluation of prostate needle biopsies in our institution.
We also retrieved the information on IHC for HMWK (cytokeratin 5/6 [CK5/6]) and AMACR ordered for the evaluation of the needle biopsies, including the specific blocks in which IHC was performed.
The first one was used for IHC, using combined HMWK (CK5/6) and AMACR, which were performed sequentially on one slide, followed by 3 deeper H & E levels as previously described.