CLEC10A

(redirected from HML2)

CLEC10A

A gene on chromosome 17p13.1 that encodes a C-type lectin domain protein which plays a role in adaptive and innate immune responses. BCLEC10A binds to terminal galactose and N-acetylgalactosamine units, which are linked to serine or threonine and seen in various carcinoma cells.
References in periodicals archive ?
ERVs have been shown to cause cancer when activated by bacteria in mice with weakened immune systems.' Dr Gkikas and colleagues are now looking to further investigate these ancient viruses, belonging to the HML2 family of viruses, for possible links with cancer and HIV.
Previous studies involving gene expression analysis have also demonstrated that allergens but not irritants may lead to upregulation of certain genes such as CCL23, CCL4, CYP27A1, HML2, NOTCH3, S100A4, and SLAM in DCs, thus providing the basis for approaches to identify skin-sensitizing chemicals [60].