HMGA1

(redirected from HMGIY)

HMGA1

A gene on chromosome 6p21 that encodes a non-histone DNA-binding protein involved in various cellular processes, such as regulating inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA.
References in periodicals archive ?
HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors.
Involvement of the HMGIY gene in mesenchymal tumors with 6p21 aberrations.
HMGA genes: High-mobility group I (HMGI) proteins, including those coded by the HMGA2 (HMGIC) and HMGA1 (HMGIY) genes, are expressed predominantly during embryonic development and are generally silenced in adult tissues.
A single genomic clone including HMGIY was found to span the breakpoint in a uterine leiomyoma with a complex rearrangement involving chromosome region 6p21.3 (36).
Interest in this region has been related in part to the frequently observed alterations of band 6p21 in other benign mesenchymal tumors, such as lipomas, and to the identification of another high mobility group gene, HMGIY (now designated HMGA1), in this region.