HMGA2

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HMGA2

A gene on chromosome 12q15 that encodes high-mobility group (non-histone chromosomal) protein isoform I-C, which regulates transcription by acting on CCNA2. It plays a key role in chromosome condensation during the meiotic G2/M transition of spermatocytes. A variation of HMGA2 was identified as an “intelligence gene” by researchers working with Project ENIGMA.
References in periodicals archive ?
HMGIC expression in human adult and fetal tissues and in uterine leiomyomata.
1992), is the chromosome 14 target gene and preferential fusion partner of HMGIC in uterine leiomyomas with t(12;14) (Amant et al.
Cytogenetic and molecular genetic analyses have revealed rearrangements of chromosomal region 12q13-15, resulting in altered expression of the HMGIC gene, a transcription factor belonging to the high mobility group of proteins.
DISCUSSION: The pathogenesis is unclear, but recently a translocation at chromosome 12 with a consequent aberrant expression of the high-mobility group protein isoform I-C (HMGIC) protein involved in DNA transcription was demonstrated.
Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma.
Although the exact etiology is not known, clonal cytogenic aberrations have been reported in some aggressive Angiomyxoma, including loss of an X chromosome, a translocation involving 12q14-15 [10], rearrangement of the HMGIC gene [2].