HMGA2

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HMGA2

A gene on chromosome 12q15 that encodes high-mobility group (non-histone chromosomal) protein isoform I-C, which regulates transcription by acting on CCNA2. It plays a key role in chromosome condensation during the meiotic G2/M transition of spermatocytes. A variation of HMGA2 was identified as an “intelligence gene” by researchers working with Project ENIGMA.

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References in periodicals archive ?

HMGIC expression in human adult and fetal tissues and in uterine leiomyomata.

Benefits and pitfalls of open power morcellation of uterine fibroids

1992), is the chromosome 14 target gene and preferential fusion partner of HMGIC in uterine leiomyomas with t(12;14) (Amant et al.

Etiology and pathogenesis of uterine leiomyomas: a review. (Research Review)

Cytogenetic and molecular genetic analyses have revealed rearrangements of chromosomal region 12q13-15, resulting in altered expression of the HMGIC gene, a transcription factor belonging to the high mobility group of proteins.

A rare case of angiomyxoma

DISCUSSION: The pathogenesis is unclear, but recently a translocation at chromosome 12 with a consequent aberrant expression of the high-mobility group protein isoform I-C (HMGIC) protein involved in DNA transcription was demonstrated.

A case of aggressive angiomyxoma presenting as a huge vulval growth

Translocation, deletion/amplification, and expression of HMGIC and MDM2 in a carcinoma ex pleomorphic adenoma.

Fine-Needle Aspiration Biopsy of Salivary Gland Lesions

Although the exact etiology is not known, clonal cytogenic aberrations have been reported in some aggressive Angiomyxoma, including loss of an X chromosome, a translocation involving 12q14-15 [10], rearrangement of the HMGIC gene [2].