expression in human adult and fetal tissues and in uterine leiomyomata.
1992), is the chromosome 14 target gene and preferential fusion partner of HMGIC
in uterine leiomyomas with t(12;14) (Amant et al.
Cytogenetic and molecular genetic analyses have revealed rearrangements of chromosomal region 12q13-15, resulting in altered expression of the HMGIC
gene, a transcription factor belonging to the high mobility group of proteins.
DISCUSSION: The pathogenesis is unclear, but recently a translocation at chromosome 12 with a consequent aberrant expression of the high-mobility group protein isoform I-C (HMGIC
) protein involved in DNA transcription was demonstrated.
Translocation, deletion/amplification, and expression of HMGIC
and MDM2 in a carcinoma ex pleomorphic adenoma.
Although the exact etiology is not known, clonal cytogenic aberrations have been reported in some aggressive Angiomyxoma, including loss of an X chromosome, a translocation involving 12q14-15 , rearrangement of the HMGIC