Expressions of both HMGB1
(6.3, 4.4-7.8 ng/mL vs 1.9, 2.4-3.3 ng/mL, P < 0.001) and TLR4 (3.0, 2.3-3.6 ng/ mL vs 0.9, 1.3-1.7 ng/mL, P< 0.001) in epilepsy patients were greatly elevated compared with HCs (Figure 1).
Septic mice HMGB1
protein expression  is reduced.
Protein Bioinformatics Revealed Secretory HMGB1
May Involve in Treg Differentiation.
Analysis of Circulating HMGB1
in APS Patients and Subjects with Pregnancy Morbidity.
Prior to the experiments, the cells were serum starved for 24 h, transfected with the HMGB1
siRNA or control siRNA for 48 h or pretreated with anti-RAGE antibodies (10 g/ml) and IgG for 1 h, and subsequently stimulated with 5-20 [micro]g/ml of PM2.5 in medium for 12-48 h.
Cucchiara et al., "Role of HMGB1
as a suitable biomarker of subclinical intestinal inflammation and mucosal healing in patients with inflammatory bowel disease," Inflammatory Bowel Diseases, vol.
is closely related to many inflammatory diseases, such as ischemia of liver and kidney, hepatitis, arthritis, stroke, ischemia of liver and kidney, sepsis, and systemic lupus erythematosus [21-25].
The differentially expressed gene Af3 shared a high homology (98%) with Bos Taurus high-mobility group box1 (HMGB1
), which is an important structural protein mainly distributed in mammalian cell nucleus (Suda et al., 2010).
Differential roles of HMGB1
inside and outside of neurons
Principales productos de los macrofagos implicados en la patogenesis de sepsis Producto Efecto tipico Citocinas IL-1, IL- 6, IL-12, IL-15, IL-18, TNF-[alpha], MIF, HMGB1
Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1
siRNA delivery in primary cortical cultures and in the postischemic brain.
Central molecules of the two most potent host defense systems that form a nexus at the crossroads of innate immunity are high mobility group box protein 1 (HMGB1
) and thrombin.