HMGA2


Also found in: Dictionary.

HMGA2

A gene on chromosome 12q15 that encodes high-mobility group (non-histone chromosomal) protein isoform I-C, which regulates transcription by acting on CCNA2. It plays a key role in chromosome condensation during the meiotic G2/M transition of spermatocytes. A variation of HMGA2 was identified as an “intelligence gene” by researchers working with Project ENIGMA.
References in periodicals archive ?
Among them, at least HES1, EGR1, JUN, JUNB, CDKN1A, CSF2, CCND1, HMGA2, and SERPINB5 have been associated with hematological neoplasia (see Tables 3 and 4).
WNT10B/[sz]-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer.
Andersson's group narrowed the search for the gene controlling beak size to a stretch of DNA that contains HMGA2 and three other genes.
Conflicting reports of specificities of the PLAG1 and HMGA2 alterations with respect to PAs exist.
Uterine leiomyomata and decreased height: a common HMGA2 predisposition allele.
HMGA2 is the partner of MDM2 in well differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon.
5] Human genes: KLK6, kallikrein-related peptidase 6; KLK10, Kallikrein-related peptidase 10; MYC, v-myc myelocytomatosis viral oncogene homolog (avian); KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; HMGA2, high mobility group AT-hook.
Il pointe ainsi une relation entre une variation genetique, egalement d'une lettre, sur le gene HMGA2 observe chez des personnes presentant un cerveau de bonne taille et de meilleures performances aux tests de QI, sur la base d'une etude aupres de 1.
They found that a variant in a gene called HMGA2 affected brain size as well as a person's intelligence.
HMGA genes: High-mobility group I (HMGI) proteins, including those coded by the HMGA2 (HMGIC) and HMGA1 (HMGIY) genes, are expressed predominantly during embryonic development and are generally silenced in adult tissues.
For example, scientists identified a correlation between the HMGA2 gene and height in humans and a similar correlation between the HMGA2 gene and size in dogs.