HMGA1

HMGA1

A gene on chromosome 6p21 that encodes a non-histone DNA-binding protein involved in various cellular processes, such as regulating inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA.
References in periodicals archive ?
reported that high mobility group protein A1 (HMGA1) modulated EC cell migration and invasion by activating Wnt/[beta]-catenin signal pathway (34).
Three polypeptides HMGA1a, HMGA1b (together HMGA1), and HMGA2 are high-mobility group A nuclear phosphoproteins that are highly expressed in undifferentiated and cancer cells, but that are noticeably absent in adult differentiated cells.
revealed that HMGA1, HMGA2, IGF2BP2, HIF3A, ARID3A, and E2F5 were the most highly induced targets of let-7 microRNAs in the context of intestinal homeostasis [31].
High mobility group protein A (HMGA) 1 suppresses expression of IGF2BP2, which in turn binds and stabilizes HMGA1 mRNA.
Brunetti, "The association between HMGA1 rs146052672 variant and type 2 diabetes: a transethnic meta-analysis," PLoS One, vol.
Three other LPP-partner genes have been reported in one case of lipoma, HMGA1 (6p21) [32], and in 2 different hematological malignancies: KMT2A(11q23) in a secondary acute leukemia [28] and BCL6(3q27) through a 3q27 interstitial deletion in a primary central nervous system lymphomas [33].
Diebold et al., "In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1 and its target slug," Circulation, vol.
Yang, "Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer," Molecular and Cellular Biochemistry, vol.
In experimental cardiac hypertrophy, MiR-195 downregulates the translation of HMGA1 by targeting its 3' UTR and this inhibition promotes hypertrophic response [37, 38].
Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits.
Those markers include HMGA1 and 2, CD163, ApoD, tenascin, S100A6, MMP2 and 11, IGFBP7, cathepsin K, and D2-40.