HMGA1

HMGA1

A gene on chromosome 6p21 that encodes a non-histone DNA-binding protein involved in various cellular processes, such as regulating inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA.
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Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation.
Those markers include HMGA1 and 2, CD163, ApoD, tenascin, S100A6, MMP2 and 11, IGFBP7, cathepsin K, and D2-40.
Remarkably, within a few days of blocking HMGA1 expression, they appeared rounder and much more like normal breast cells growing in culture.
In a previous study, she and her team devised techniques to block the HMGA1 gene in stem cells in order to study its role in those cells.
Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion.
HMGA genes: High-mobility group I (HMGI) proteins, including those coded by the HMGA2 (HMGIC) and HMGA1 (HMGIY) genes, are expressed predominantly during embryonic development and are generally silenced in adult tissues.
The investigators examined variations in the high-mobility group A1 protein, or HMGA1, a key regulator of insulin receptor gene expression.
The HMGA1 polymorphisms are consistently associated with fat deposition traits across several pig populations, except for a pure Duroc in which the distribution of a specific HMGA1 genotypic class was relatively small (Kim et al.
Washington, March 3 (ANI): A new study has found that certain variations of the gene HMGA1 are associated with type 2 diabetes mellitus for individuals of white European descent.
Washington, March 2 (ANI): A new study has found that certain variations of the gene HMGA1 are associated with type 2 diabetes mellitus for individuals of white European descent.
The loss of expression by disrupting the HMGA1 gene affects insulin signaling and causes diabetes in the mouse.