reported that high mobility group protein A1 (HMGA1
) modulated EC cell migration and invasion by activating Wnt/[beta]-catenin signal pathway (34).
Three polypeptides HMGA1a, HMGA1b (together HMGA1
), and HMGA2 are high-mobility group A nuclear phosphoproteins that are highly expressed in undifferentiated and cancer cells, but that are noticeably absent in adult differentiated cells.
revealed that HMGA1
, HMGA2, IGF2BP2, HIF3A, ARID3A, and E2F5 were the most highly induced targets of let-7 microRNAs in the context of intestinal homeostasis .
High mobility group protein A (HMGA) 1 suppresses expression of IGF2BP2, which in turn binds and stabilizes HMGA1
Brunetti, "The association between HMGA1
rs146052672 variant and type 2 diabetes: a transethnic meta-analysis," PLoS One, vol.
Three other LPP-partner genes have been reported in one case of lipoma, HMGA1
(6p21) , and in 2 different hematological malignancies: KMT2A(11q23) in a secondary acute leukemia  and BCL6(3q27) through a 3q27 interstitial deletion in a primary central nervous system lymphomas .
Diebold et al., "In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1
and its target slug," Circulation, vol.
In prostate cancer cells, miR-195 functions as a tumor suppressor gene by suppressing HMGA1
Yang, "Overexpression of HMGA1
correlates with the malignant status and prognosis of breast cancer," Molecular and Cellular Biochemistry, vol.
In experimental cardiac hypertrophy, MiR-195 downregulates the translation of HMGA1
by targeting its 3' UTR and this inhibition promotes hypertrophic response [37, 38].
Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1
) polymorphisms with pig growth and fat deposition traits.
Those markers include HMGA1
and 2, CD163, ApoD, tenascin, S100A6, MMP2 and 11, IGFBP7, cathepsin K, and D2-40.