HMG-CoA reductase inhibitor


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Related to HMG-CoA reductase inhibitor: hypoglycemia, simvastatin

HMG-CoA reductase inhibitor

any of a group of drugs that competitively inhibit the enzyme catalyzing the rate-limiting step in cholesterol biosynthesis and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Also called statin.
References in periodicals archive ?
HMG-CoA reductase inhibitors for treatment of hypercholesterolemia.
There are occasions, however, when this general rule does not hold true, including for the HMG-CoA reductase inhibitor study we have described, which produced larger increases in ALT relative to AST without an associated liver toxicity.
Pharmanex maintains that Cholestin is a supplement derived from red yeast rice, a traditional Chinese remedy, and that lovastatin is one of only 10 substances containing HMG-CoA reductase inhibitors that are found in the product.
In preventive cardiology, one of the major breakthroughs has been the reduction in cardiovascular events as a result of the introduction of HMG-CoA reductase inhibitors (10-12), commonly known as statins.
This process is usually accomplished through inhibition of cholesterol synthesis with HMG-CoA reductase inhibitors (Corsini et al.
Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography (CCAIT).
Cerivastatin, a HMG-CoA reductase inhibitor, improves endothelial function in elderly diabetics within 3 days.
This is the largest amount of data ever submitted for approval of an HMG-CoA reductase inhibitor.
Current consensus is that virtually everyone with known coronary disease ought to be on an HMG-CoA reductase inhibitor, regardless of LDL cholesterol level.