HMG-CoA reductase


Also found in: Dictionary, Thesaurus, Wikipedia.
Related to HMG-CoA reductase: Mevalonate

HMG-CoA reductase

a rate-controlling enzyme of cholesterol synthesis. Activity of the enzyme may be as much as 60 times higher than normal in patients with low-density lipoprotein receptor disorder.
References in periodicals archive ?
A bioactive compound known as lovastatin, found in high concentrations in the extract, successfully inhibited HMG-CoA reductase in an experiment designed to test the enzyme's activity.
HMG-CoA reductase was measured using double-antibody sandwich enzyme-linked immunosorbent technique using commercial mouse hydroxymethylglutaryl CoA reductase (HMG-CoA) ELISA kit (Shanghai Crystal Day Biotech Co.
The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981.
HMG-CoA reductase inhibitors (statins) have been tried to lower 7DHC levels but they didn't reduce the cholesterol levels (7, 8).
They block the action of the enzyme HMG-CoA reductase in the liver that is used for making cholesterol.
Inhibition of the enzyme HMG-CoA reductase and the subsequent blockade of the mevalonate pathway is probably the most important mechanism of inhibition of bone resorption by statins.
8,9) Furthermore, mevinolin, a specific inhibitor of HMG-CoA reductase, did not inhibit the growth of E.
These drugs are competitive inhibitors of HMG-CoA reductase, which catalyzes an early rate limiting step in cholesterol biosynthesis.
Statins, or HMG-CoA reductase inhibitors, are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver.
Experimental parameters included serum lipid levels, hepatic lipid peroxidation, levels of HMG-CoA reductase and antioxidant profiles.