HMG-CoA

Abbreviation for β-hydroxy-β-methylglutaryl-CoA.

References in periodicals archive ?

A bioactive compound known as lovastatin, found in high concentrations in the extract, successfully inhibited HMG-CoA reductase in an experiment designed to test the enzyme's activity.

Fermenting fish to reduce cholesterol

It has longer plasma half-life of 14 hours and metabolized extensively by cytochrome P450 3A4 (CYP3A4) enzymes, producing two active metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin both of which inhibit HMG-CoA reductase activity11.

PHARMACOKINETIC STUDY OF ATORVASTATIN AFTER SINGLE DOSE ADMINISTRATION AMONG PAKISTANI POPULATION

HMG-CoA reductase was measured using double-antibody sandwich enzyme-linked immunosorbent technique using commercial mouse hydroxymethylglutaryl CoA reductase (HMG-CoA) ELISA kit (Shanghai Crystal Day Biotech Co.

Modulating liver cholesterol metabolism by 3-iodothyronamine

Inhibition of HMG-CoA reductase (2011) activity and enhanced reactive vasodilation Di Donna et al.

The effect of bergamot on dyslipidemia

IL-6 a key factor in growth inhibition of human myeloma cells induced by pravastatin, en HMG-CoA reductase inhibitor.

Pravastatin induces cell cycle arrest and decreased production of VEGF and bFGF in multiple myeloma cell line/Pravastatina induz parada no ciclo celular e diminuicao na producao de VEGF e bFGF em linhagem de Mieloma Multiplo

Its product HMG-CoA is broken down into acetoacetate and 2-hydroxybutyrate by HMG-CoA lyase.

RESEARCH ADVANCE OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A SYNTHASE IN PLANT ISOPRENOID BIOSYNTHESIS

The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981.

Use of Atorvastatin in Lipid Disorders and Cardiovascular Disease in Chinese Patients

They block the action of the enzyme HMG-CoA reductase in the liver that is used for making cholesterol.

Statins said to reduce cancer deaths: but benefit is tied to existing statin use preceding a cancer diagnosis, not to statins as a cancer preventive

The hydroxyacid of the second chain forms a six membered analogue of the intermediate compound in the HMG-CoA reductase reaction, which is the rate-limiting step in the mevalonate pathway.

Statins in periodontal regeneration --the current scenario

This CoA-derivative is reduced to MVA by HMG-CoA reductase, which is the rate-limiting enzyme of the MVA pathway in humans.

Two distinct pathways for essential metabolic precursors for isoprenoid biosynthesis

Statins, or HMG-CoA reductase inhibitors, are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver.

Cholesterol-lowering drugs linked to reducing influenza patients' mortality

Experimental parameters included serum lipid levels, hepatic lipid peroxidation, levels of HMG-CoA reductase and antioxidant profiles.