HMG-CoA


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HMG-CoA

References in periodicals archive ?
A bioactive compound known as lovastatin, found in high concentrations in the extract, successfully inhibited HMG-CoA reductase in an experiment designed to test the enzyme's activity.
It has longer plasma half-life of 14 hours and metabolized extensively by cytochrome P450 3A4 (CYP3A4) enzymes, producing two active metabolites ortho-hydroxy atorvastatin and para-hydroxy atorvastatin both of which inhibit HMG-CoA reductase activity11.
HMG-CoA reductase was measured using double-antibody sandwich enzyme-linked immunosorbent technique using commercial mouse hydroxymethylglutaryl CoA reductase (HMG-CoA) ELISA kit (Shanghai Crystal Day Biotech Co.
Inhibition of HMG-CoA reductase (2011) activity and enhanced reactive vasodilation Di Donna et al.
Its product HMG-CoA is broken down into acetoacetate and 2-hydroxybutyrate by HMG-CoA lyase.
The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981.
They block the action of the enzyme HMG-CoA reductase in the liver that is used for making cholesterol.
The hydroxyacid of the second chain forms a six membered analogue of the intermediate compound in the HMG-CoA reductase reaction, which is the rate-limiting step in the mevalonate pathway.
This CoA-derivative is reduced to MVA by HMG-CoA reductase, which is the rate-limiting enzyme of the MVA pathway in humans.
Statins, or HMG-CoA reductase inhibitors, are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver.
Experimental parameters included serum lipid levels, hepatic lipid peroxidation, levels of HMG-CoA reductase and antioxidant profiles.