HMG CoA reductase inhibitor

HMG CoA reductase inhibitor

Any of a family of drugs, statins, that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A, which is involved in early cholesterol synthesis. See Atherosclerosis, Cholesterol.

Patient discussion about HMG CoA reductase inhibitor

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

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References in periodicals archive ?
So the decrease of brain serotonin level in the present study following 4 week administration of HMG CoA reductase inhibitor could be due to the altered serum lipids.
In patients who had experienced an acute coronary event, in a trial called PROVE-IT-TIMI22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22), we observed that more-intensive lowering of the LDL-C concentration with a high dose of a very potent HmG CoA reductase inhibitor (80 mg/day atorvastatin) to an average LDL-C of 62 mg/dL (1.
The keywords used were statins, periodontal regeneration, mevalonate pathway, HMG CoA reductase inhibitors.
So the researchers began a systematic investigation of organisms that might produce HMG CoA reductase inhibitors.