The aim of the present study was to evaluate the effect of HMG CoA reductase inhibitor
Pitavastatin, on glycemic control in patients with type 2 diabetes who were previously being treated with Atorvastatin.
Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor
, on monocyte-endothelial cell adhesion.
So the decrease of brain serotonin level in the present study following 4 week administration of HMG CoA reductase inhibitor
could be due to the altered serum lipids.
In patients who had experienced an acute coronary event, in a trial called PROVE-IT-TIMI22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22), we observed that more-intensive lowering of the LDL-C concentration with a high dose of a very potent HmG CoA reductase inhibitor
(80 mg/day atorvastatin) to an average LDL-C of 62 mg/dL (1.6 mmol/L) led to significantly better clinical outcomes than those achieved by 40 mg pravastatin daily [95 mg/dL (2.5 mmol/L)], the regimen that had been found in the CARE trial to be superior to placebo (11).
HMG CoA reductase inhibitors
(statins) for kidney transplant recipients.
The keywords used were statins, periodontal regeneration, mevalonate pathway, HMG CoA reductase inhibitors
. For further refinement, the following exclusion criteria were defined: Publications were limited to those of English language and from the scientific, peer-reviewed literature.
So the researchers began a systematic investigation of organisms that might produce HMG CoA reductase inhibitors
. Molds of the penicillium species were good candidates because they produce compounds that interfere with life, i.e., the "antibiotics." In 1976, Ando isolated a compound from a mold fermentation broth that turned out to be an effective inhibitor of cholesterol biosynthesis.
The University of Sydney Table 1 Drugs whose metabolism is inhibited and bioavailability increased by grapefruit juice (6,7) Anti-hypertensive Calcium channel blockers FELODPINE ('Agon'; 'felodur'; 'Plendil' NIFEDIPINE ('Adalat'; 'Nyefax') NISOLDIPINE NITRENDIPINE NIMODIPINE ('Nimotop') Certain HMG CoA Reductase inhibitors
SIMVASTATIN ('Lipex'; 'Zocor') LOVASTATIN ATORVASTATIN ('Lipitor') Immunomodifiers CYCLOSPORIN ('Neoral') TACROLIMUS ('Prograf') An Anti-convulsant CARBAMAZEPINE ('Tegretol') Certain Benzodiazepine sedatives MIDAZOLAM ('Hypnovel') TRIAZOLAM ('Halcion') Certain Anti-viral agents INDINAVIR ('Crixivan') SAQUINAVIR ('Invirase'; 'Fortovase') GI Motility stimulant CISAPRIDE ('Prepulsid') An Azopirone Anxiolytic BUSPIRONE ('Buspar') (9)