HMG CoA reductase inhibitor

HMG CoA reductase inhibitor

Any of a family of drugs, statins, that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A, which is involved in early cholesterol synthesis. See Atherosclerosis, Cholesterol.

Patient discussion about HMG CoA reductase inhibitor

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

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References in periodicals archive ?
The aim of the present study was to evaluate the effect of HMG CoA reductase inhibitor Pitavastatin, on glycemic control in patients with type 2 diabetes who were previously being treated with Atorvastatin.
Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion.
So the decrease of brain serotonin level in the present study following 4 week administration of HMG CoA reductase inhibitor could be due to the altered serum lipids.
In patients who had experienced an acute coronary event, in a trial called PROVE-IT-TIMI22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22), we observed that more-intensive lowering of the LDL-C concentration with a high dose of a very potent HmG CoA reductase inhibitor (80 mg/day atorvastatin) to an average LDL-C of 62 mg/dL (1.6 mmol/L) led to significantly better clinical outcomes than those achieved by 40 mg pravastatin daily [95 mg/dL (2.5 mmol/L)], the regimen that had been found in the CARE trial to be superior to placebo (11).
HMG CoA reductase inhibitors (statins) for kidney transplant recipients.
The keywords used were statins, periodontal regeneration, mevalonate pathway, HMG CoA reductase inhibitors. For further refinement, the following exclusion criteria were defined: Publications were limited to those of English language and from the scientific, peer-reviewed literature.
So the researchers began a systematic investigation of organisms that might produce HMG CoA reductase inhibitors. Molds of the penicillium species were good candidates because they produce compounds that interfere with life, i.e., the "antibiotics." In 1976, Ando isolated a compound from a mold fermentation broth that turned out to be an effective inhibitor of cholesterol biosynthesis.
The University of Sydney Table 1 Drugs whose metabolism is inhibited and bioavailability increased by grapefruit juice (6,7) Anti-hypertensive Calcium channel blockers FELODPINE ('Agon'; 'felodur'; 'Plendil' NIFEDIPINE ('Adalat'; 'Nyefax') NISOLDIPINE NITRENDIPINE NIMODIPINE ('Nimotop') Certain HMG CoA Reductase inhibitors SIMVASTATIN ('Lipex'; 'Zocor') LOVASTATIN ATORVASTATIN ('Lipitor') Immunomodifiers CYCLOSPORIN ('Neoral') TACROLIMUS ('Prograf') An Anti-convulsant CARBAMAZEPINE ('Tegretol') Certain Benzodiazepine sedatives MIDAZOLAM ('Hypnovel') TRIAZOLAM ('Halcion') Certain Anti-viral agents INDINAVIR ('Crixivan') SAQUINAVIR ('Invirase'; 'Fortovase') GI Motility stimulant CISAPRIDE ('Prepulsid') An Azopirone Anxiolytic BUSPIRONE ('Buspar') (9)