HMB-45


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HMB-45

An antibody to a premelanosome glycoprotein found to be present in melanomas and other tumors derived from melanocytes.
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1) Renal leiomyomas can be differentiated from angiomyolipoma with the lack of a fat component and lack of expression of melanocytic markers, such as HMB-45 and Melan-A.
Clear cell sarcoma of the GI tract expresses S100 protein, but in contrast to its soft-tissue counterpart, it often does not stain with other melanocytic markers such as HMB-45 or melanoma-associated antigen recognized by T cells 1 (MART-1).
Olguya uygulanan immunohistokimyasal incelemelerde, tumor hucrelerinde HMB-45 ve MART-1 melanin ile yaygin pozitif boyanma elde edildi (Resim 2).
Biopsy of a mass provides the diagnosis and when the biopsies are inconclusive immunohistochemical stains which include HMB-45 and S-100 are useful to confirm melanoma.
The tumor cells were immunohistochemically positive for S-100 protein, HMB-45, Melan-A, and PNL-2.
Antibodies to S100, HMB-45, keratin AE1/AE3, and thyroglobulin were applied to paraffin sections using peroxidase immunohistochemistry.
He recommends more aggressive immunohisto-chemical analysis than average, including routine HMB-45 and S100 stains and serial step sectioning through the node.
Diffuse expression of S-100 protein and absence of staining with antibodies to cytokeratin and HMB-45 were observed.
12) Recently studies (13) showed that immunohistochemical analysis with HMB-45 is useful in differentiating between AML and other neoplasm of the kidney.
S-100 was the most commonly used immunohistochemical stain (78%), followed by Melan-A (56%), MART-1 (50%), HMB-45 (44%), tyrosinase (33%), MiTF (11%), and pan-melanoma (6%) (Figure 3).
JXG lesions also stain positively for factor XIIIa, and HAM-56 and negatively for CDla, CD3, CD20, S-100 protein, HMB-45, cytokeratins, actin, and desmin.