HMB-45

Also found in: Wikipedia.

HMB-45

An antibody to a premelanosome glycoprotein found to be present in melanomas and other tumors derived from melanocytes.

Mentioned in ?

melanotic schwannoma

References in periodicals archive ?

The cells showed a positive reaction for HMB-45 antigen [Figure 1]b.

Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex

400x magnified images are given in Figure 2, 3, 4 with the actin, HMB-45 and haematoxylin and eosin staining of the mass.

Perivascular Epithelioid Cell Tumor of the Kidney: A Rare Case Report / Bobregin Perivaskuler Epiteloid Hucre Tumoru: Nadir Bir Olgu Sunumu

The tumor showed positive staining for Desmin (Figure 3), and negative for HMB-45 and S-100.

Angiomyolipoma of the cervix--report of a rare entity

The effect of mitotic index, pigmentation, S100, HMB-45, Melan-A and C-KIT on survival were evaluated.

Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Immunohistochemistry was performed with markers like keratin, vimentin and HMB-45 to know the histogenesis of tumour.

Vulvar sarcomatoid carcinoma- a case report of an unusual variant at an unusual site

Additional immunostains performed at our institution revealed negative staining of the lesional cells for wide spectrum cytokeratin (CK), CK OSCAR (Figure 5A), epithelial membrane antigen (EMA), S100, HMB-45, smooth muscle actin and positive staining for CD34, desmin (Figure 5 B), estrogen receptor (Figure 6), and BCL-2.

Myofibroblastoma of the breast

13-16,18-20,22-27) The melanocytic marker HMB-45 is expressed in all cases, and Melan-A is positive in up to 80% of tumors.

Predicting the Behavior of Perivascular Epithelioid Cell Tumors of the Uterine Corpus

7,8) Markers associated with malignant melanoma include S-100 protein, gp 100, MART-1, tyrosinase, NK1/ C3, vimentin, HMB-45, and KBA.

A case of radiation-induced mucosal melanoma in an immunohistochemically S-100-negative patient

Some ONB can show focal melanin pigment and rare positivity for HMB-45 but positivity for neuroendocrine markers, negativity for Melan-A and careful interpretation of Masson Fontana rules out sinonasal melanoma.

Olfactory neuroblastoma: A clinicopathological experience of a rare entity from Pakistan

4) The smooth muscle component of AML (and other PEComas) stains positive not only for actin and desmin but also for melanocytic markers such as HMB-45 and Melan-A.

Aneurysm in a large sporadic renal angiomyolipoma

In a number of studies, the Melan-A marker was shown to be more specific and sensitive than the S-100 and HMB-45 melanocytic markers (14, 20, 22-24).

Immunohistochemical analysis of melanocyte content in different zones of vitiligo lesions using the Melan-A marker

Histological examination of a renal leiomyoma reveals fusiform to spindle shaped cells with positive immunohistochemical staining for smooth muscle markers (desmin, caldesmon, and SMA) and negative staining for HMB-45 and cathepsin K.