HCAR2

(redirected from HM74A)

HCAR2

A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor. HCAR2 is a high-affinity receptor for nicotinic acid/niacin and for beta-hydroxybutyrate; it increases adiponectin secretion and reduces lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase.
References in periodicals archive ?
Niacin, through HM74a receptor (coupled to Gi/o proteins [143]), reduces basal [140, 144, 145] and noradrenaline-(NA-) induced release of plasma FFA [146] and inhibits lipolysis [144-146].
Binding of niacin to HM74a receptor increases adiponectin secretion in adipocytes from MS patients [145].
The mechanism involved in the overexpression of these factors is unclear, although it has been pointed out as a role for HM74a as the initial trigger [140].
GPR109A, also known as hydroxy-carboxylic acid 2 receptor or HM74a, is a receptor for nicotinate.